NCT06796374: FISEKIN-1

A Comparison of Fisetin Kinetics in Young and Old Adults

Recruiting now NA Last updated 6 April 2026

What this trial tests

NA trial testing Fisetin - Fasted condition in Pharmacokinetic Study in Healthy Volunteers in 80 participants. Currently enrolling.

Timeline

31 March 2026

Primary endpoint
30 June 2027

31 July 2027

Quick facts

Lead sponsor	University Medicine Greifswald
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	basic science
Enrollment	80
Start date	31 March 2026
Primary completion	30 June 2027
Estimated completion	31 July 2027
Sites	1 location across Germany

Drugs / interventions tested

• Fisetin - Fasted condition
• Fisetin - Fed condition

Conditions studied

• Pharmacokinetic Study in Healthy Volunteers — all drugs for Pharmacokinetic Study in Healthy Volunteers →

Sponsor

University Medicine Greifswald

Who can join

18 and older, any sex, with Pharmacokinetic Study in Healthy Volunteers. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study investigates the differences in the kinetic parameters of fisetin in two cohorts of healthy volunteers:

Cohort 1) volunteers aged 18-30 years (n = 40) Cohort 2) volunteers aged 65 years or older (n = 40)

The purpose of this study is:

1. To describe the fisetin kinetics after a single dose oral administration in older age.
2. To compare the fisetin kinetics after a single dose oral administration in old and young age.

FISEKIN-1 is designed as a four-arm study protocol. As well as two different age groups (18-30 years vs. 65 years and older), we want to compare fisetin kinetic parameters in fasted and fed condition:

Arm 1) 500 mg fisetin (1x 5 capsule), fasted condition, cohort 1: young age Arm 2) 500 mg fisetin (1x 5 capsule), fasted condition, cohort 2: old age Arm 3) 500 mg fisetin (1x 5 capsule), fed condition, cohort 1: young age Arm 4) 500 mg fisetin (1x 5 capsule), fed condition, cohort 2: old age

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Beneficial Effects of Fisetin, a Senotherapeutic Compound, in Women's Reproductive Health and Diseases: Evidence from In Vitro to Clinical Studies.
   El Sayed S, Saiyed D, Macri VI, Asamoah-Mensah A, et al · · 2026 · PMID 41683217 · DOI 10.3390/nu18030393