NCT04330677 (ESMory) is a Phase 1 clinical trial of Oxytocin nasal spray in Oxytocin, sponsored by University Hospital, Bonn.

Who is sponsoring NCT04330677?

NCT04330677 is sponsored by University Hospital, Bonn.

What drugs are being tested in NCT04330677?

Interventions in NCT04330677: Oxytocin nasal spray, Placebo nasal spray, Estrogen Gel, Placebo Gel.

What condition does NCT04330677 study?

NCT04330677 studies Oxytocin, Estrogen, Fear Extinction, Emotion Processing, Memory.

Is NCT04330677 still recruiting?

NCT04330677 is currently completed. Last updated 7 April 2020.

Last reviewed 2020-04-07 · How we verify

NCT04330677: ESMory

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Dissecting the Role of Estradiol in Mediating Gender-specific Anxiolytic and Prosocial Effects of Oxytocin

Completed Phase 1 Last updated 7 April 2020

What this trial tests

Phase 1 trial testing Oxytocin nasal spray in Oxytocin in 487 participants. Completed in 25 January 2020.

Timeline

18 September 2016

Primary endpoint
25 January 2020

25 January 2020

Quick facts

Lead sponsor	University Hospital, Bonn
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	factorial
Masking	double
Primary purpose	basic science
Enrollment	487
Start date	18 September 2016
Primary completion	25 January 2020
Estimated completion	25 January 2020
Sites	1 location across Germany

Drugs / interventions tested

Oxytocin nasal spray — full drug profile →
Placebo nasal spray — full drug profile →
Estrogen Gel
Placebo Gel

Conditions studied

Oxytocin — all drugs for Oxytocin →
Estrogen — all drugs for Estrogen →
Fear Extinction — all drugs for Fear Extinction →
Emotion Processing — all drugs for Emotion Processing →

Sponsor

University Hospital, Bonn

Who can join

Adults 18 to 40, any sex, with Oxytocin or Estrogen. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The study aims to examine a behavioral and neural framework for understanding the sex-specific effects of the neuropeptide oxytocin (OXT). Using hormonal, behavioral and neuroimaging readouts, it is planned to explore the interplay of OXT and estradiol as a potential mechanism mediating sexual dimorphic effects.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Effects of exogenous oxytocin and estradiol on resting-state functional connectivity in women and men.
Coenjaerts M, Adrovic B, Trimborn I, Philipsen A, et al · · 2023 · cited 14× · PMID 36813823 · DOI 10.1038/s41598-023-29754-y

Verify or expand the search:

Other trials of Oxytocin nasal spray

Trials testing the same drug.

NCT07162584 — Oxytocin and Human Defensive Responses in a Dynamic Situation · NA · recruiting
NCT06194851 — Examining Intranasal Oxytocin Augmentation of Brief Couples Therapy for Veterans With PTSD · Phase 2 · recruiting
NCT05934812 — Intranasal Oxytocin in Youth With Autism · Phase 2 · not yet recruiting
NCT06881810 — Enhancing Social Skills in Schizophrenia Spectrum Disorders - Oxytocin as add-on to Psychosocial Treatment · Phase 2 · recruiting
NCT06332066 — Oxytocin Administration to Therapists and Its Effects on Patient-perceived Attunement and Responsiveness · Phase 1 · unknown

Other recruiting trials for Oxytocin

Currently open trials in the same condition.

NCT07351799 — Mindfulness and Meditation Based Lactation Education on Maternal Breastmilk in the Neonatal ICU · NA · recruiting
NCT04551482 — Oxytocin for Weight Loss in Adolescents · Phase 2 · recruiting

Other University Hospital, Bonn trials

Trials by the same sponsor.

NCT07291765 — Blood Flow Restriction Training in Acute Geriatric Rehabilitation: A Randomized Controlled Trial on Its Effects and Safe · NA · not yet recruiting
NCT07324330 — Slowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical Activity · NA · recruiting
NCT07299591 — Analysis of Pharmacological Aspects Regarding Infection Free Survival After Surgical Treatment of a Periprosthetic Hip I · recruiting
NCT07299565 — Analysis of Pharmacological Aspects Regarding Infection Free Survival After Surgical Treatment of a Periprosthetic Knee · recruiting
NCT07043569 — Clinical-randomized Trial of the Effect of Rehabilitation Therapy Using Strength and Blood Flow Restriction Training on · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04330677 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Bonn
Last refreshed: 7 April 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04330677.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing