Who is sponsoring NCT06194851?

NCT06194851 is sponsored by VA Office of Research and Development.

What drugs are being tested in NCT06194851?

Interventions in NCT06194851: Oxytocin nasal spray, Saline nasal spray, Brief Cognitive-Behavioral Conjoint Therapy.

What condition does NCT06194851 study?

NCT06194851 studies Post-Traumatic Stress Disorder (PTSD).

Is NCT06194851 still recruiting?

NCT06194851 is currently recruiting now. Last updated 29 May 2025.

Last reviewed 2025-05-29 · How we verify

NCT06194851: CBCT-OT RCT

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Examining Intranasal Oxytocin Augmentation of Brief Couples Therapy for Veterans With PTSD

Recruiting now Phase 2 Last updated 29 May 2025

What this trial tests

Phase 2 trial testing Oxytocin nasal spray in Post-Traumatic Stress Disorder (PTSD) in 240 participants. Currently enrolling.

Timeline

28 October 2024

Primary endpoint
30 April 2028

30 April 2028

Quick facts

Lead sponsor	VA Office of Research and Development
Phase	Phase 2
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	240
Start date	28 October 2024
Primary completion	30 April 2028
Estimated completion	30 April 2028
Sites	1 location across United States

Drugs / interventions tested

Oxytocin nasal spray — full drug profile →
Saline nasal spray — full drug profile →
Brief Cognitive-Behavioral Conjoint Therapy

Conditions studied

Post-Traumatic Stress Disorder (PTSD) — all drugs for Post-Traumatic Stress Disorder (PTSD) →

Sponsor

VA Office of Research and Development — full company profile →

Who can join

18 and older, any sex, with Post-Traumatic Stress Disorder (PTSD). Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Leveraging veterans' intimate relationships during treatment for posttraumatic stress disorder (PTSD) has the potential to concurrently improve PTSD symptoms and relationship quality. Brief Cognitive-Behavioral Conjoint Therapy (bCBCT) is a manualized treatment designed to simultaneously improve PTSD and relationship functioning for couples in which one partner has PTSD. Although efficacious in improving PTSD, the effects of CBCT on relationship satisfaction are small, especially among Veterans. Pharmacological augmentation of bCBCT with intranasal oxytocin, a neurohormone that influences mechanisms of trauma recovery and social behavior, may help improve the efficacy of bCBCT. The purpose of this randomized placebo-controlled trial is to compare the clinical and functional outcomes of bCBCT augmented with intranasal oxytocin (bCBCT + OT) versus bCBCT plus placebo (bCBCT + PL). The investigators will also explore potential mechanisms of action: communication, empathy, and trust.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Design of a randomized clinical trial of brief couple therapy for PTSD augmented with intranasal oxytocin.
Sippel LM, Wachsman TR, Kelley ME, Knopp KC, et al · · 2024 · cited 2× · PMID 38614447 · DOI 10.1016/j.cct.2024.107534

Verify or expand the search:

Other trials of Oxytocin nasal spray

Trials testing the same drug.

NCT07162584 — Oxytocin and Human Defensive Responses in a Dynamic Situation · NA · recruiting
NCT05934812 — Intranasal Oxytocin in Youth With Autism · Phase 2 · not yet recruiting
NCT06881810 — Enhancing Social Skills in Schizophrenia Spectrum Disorders - Oxytocin as add-on to Psychosocial Treatment · Phase 2 · recruiting
NCT06332066 — Oxytocin Administration to Therapists and Its Effects on Patient-perceived Attunement and Responsiveness · Phase 1 · unknown
NCT06248710 — Dog Presence and Oxytocin on Trust Towards Therapists · Phase 2, PHASE3 · recruiting

Other VA Office of Research and Development trials

Trials by the same sponsor.

NCT07456150 — Personalizing Veteran Pain Care: Adapting Coaching Interventions to Support Maintenance of Self-Care · Phase 1 · not yet recruiting
NCT06746727 — The Development of a Transdiagnostic Intervention to Improve Social Functioning and Intimate Relationships Among Veteran · NA · not yet recruiting
NCT07362576 — Perinatal Peer Support for Veterans With Serious Mental Illness · NA · not yet recruiting
NCT06766331 — Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans · NA · not yet recruiting
NCT07397195 — ACT for Veterans With IBD and Mental Health Challenges · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06194851 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by VA Office of Research and Development
Last refreshed: 29 May 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06194851.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing