NCT04325191 is a NA clinical trial of Melatonin in Cardiovascular Risk Factor, sponsored by University of Delaware.

Who is sponsoring NCT04325191?

NCT04325191 is sponsored by University of Delaware.

What drugs are being tested in NCT04325191?

Interventions in NCT04325191: Melatonin, Placebo.

What condition does NCT04325191 study?

NCT04325191 studies Cardiovascular Risk Factor.

Is NCT04325191 still recruiting?

NCT04325191 is currently status unknown. Last updated 28 April 2021.

Last reviewed 2021-04-28 · How we verify

NCT04325191

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Melatonin and Salt on Blood Vessel Function

Status unknown NA Last updated 28 April 2021

What this trial tests

NA trial testing Melatonin in Cardiovascular Risk Factor in 15 participants. Status unknown.

Timeline

12 March 2020

Primary endpoint
30 June 2022

30 September 2022

Quick facts

Lead sponsor	University of Delaware
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	prevention
Enrollment	15
Start date	12 March 2020
Primary completion	30 June 2022
Estimated completion	30 September 2022
Sites	1 location across United States

Drugs / interventions tested

Melatonin (MELATONIN) — full drug profile →
Placebo

Conditions studied

Cardiovascular Risk Factor — all drugs for Cardiovascular Risk Factor →

Sponsor

University of Delaware

Who can join

Adults 18 to 45, any sex, with Cardiovascular Risk Factor. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Increased dietary sodium causes increases in oxidative stress and damages blood vessels. Americans eat more than the recommended amount of sodium. Melatonin is a powerful endogenous antioxidant that has reduced oxidative stress levels in clinical and healthy populations. This study will investigate whether melatonin can attenuate the negative effects of sodium on blood vessels.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Melatonin supplementation reduces nighttime blood pressure but does not affect blood pressure reactivity in normotensive adults on a high-sodium diet.
Ramos Gonzalez M, Axler MR, Kaseman KE, Lobene AJ, et al · · 2023 · cited 6× · PMID 37642281 · DOI 10.1152/ajpregu.00101.2023
Melatonin supplementation does not alter vascular function or oxidative stress in healthy normotensive adults on a high sodium diet.
Ramos Gonzalez M, Axler MR, Kaseman KE, Lobene AJ, et al · · 2023 · cited 4× · PMID 38110301 · DOI 10.14814/phy2.15896

Verify or expand the search:

Other trials of Melatonin

Trials testing the same drug.

NCT07221968 — Melatonin for the Treatment of DEE-SWAS · Phase 2 · not yet recruiting
NCT07503600 — The Effect of Adjunctive Melatonin With Colistin in Patients With Multidrug-Resistant Gram-Negative Bacterial Infections · Phase 3 · not yet recruiting
NCT07375342 — Melatonin for Post Tonsillectomy Emergence Agitation in Pediatric · NA · enrolling by invitation
NCT07305350 — EFFICACY OF MELATONIN IN MANAGEMENT OF HYPOXIC ISCHEMIC ENCEPHALOPATHY (HIE) IN NEONATES · Phase 2 · active not recruiting
NCT07096635 — Oral Melatonin With Intra Articular Analgesia on Pain After Arthroscopic Anterior Cruciate Ligament Reconstruction · NA · not yet recruiting

Other recruiting trials for Cardiovascular Risk Factor

Currently open trials in the same condition.

NCT07268781 — Impact of Golden Rice-Piper Crocatum Cookies on Lipid Control in Diabetes Mellitus Patients · NA · active not recruiting
NCT06225544 — Lumasiran in Hyperoxalaemic Patients on Haemodialysis · Phase 2 · recruiting
NCT06372054 — TORNADO-Omics Techniques and Neural Networks for the Development of Predictive Risk Models · recruiting
NCT05887622 — The Potassium Supplementation Study · NA · recruiting
NCT04962061 — A Combined Multidomain Intervention to Prevent Cognitive Decline Associated With Cardiovascular Risk Factors. · NA · recruiting

Other University of Delaware trials

Trials by the same sponsor.

NCT07420218 — Menopausal Hormones and Sympathetic Activation · Phase 4 · not yet recruiting
NCT07536217 — Developmental Pilot of Support Groups for Caregivers of Children With DLD · NA · enrolling by invitation
NCT07054840 — Pain and Split-belt Motor Learning in Older Adults · NA · recruiting
NCT06916260 — Light Therapy Intervention in Individuals With Parkinson's Disease · NA · recruiting
NCT07071077 — Examining the Feasibility of Implementing a Hypertension Storytelling Intervention Among African Americans · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04325191 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Delaware
Last refreshed: 28 April 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04325191.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing