NCT04962061 (ACTIONcR) is a NA clinical trial of Cognitive Training in Aging, sponsored by Louis Bherer.

Who is sponsoring NCT04962061?

NCT04962061 is sponsored by Louis Bherer.

What drugs are being tested in NCT04962061?

Interventions in NCT04962061: Cognitive Training, Aerobic and resistance exercises, Stretching and Toning.

What condition does NCT04962061 study?

NCT04962061 studies Aging, Cardiovascular Risk Factor.

Is NCT04962061 still recruiting?

NCT04962061 is currently recruiting now. Last updated 6 February 2025.

Last reviewed 2025-02-06 · How we verify

NCT04962061: ACTIONcR

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

A Combined Multidomain Intervention to Prevent Cognitive Decline Associated With Cardiovascular Risk Factors.

Recruiting now NA Last updated 6 February 2025

What this trial tests

NA trial testing Cognitive Training in Aging in 159 participants. Currently enrolling.

Timeline

1 September 2021

Primary endpoint
31 December 2025

31 December 2025

Quick facts

Lead sponsor	Louis Bherer
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	prevention
Enrollment	159
Start date	1 September 2021
Primary completion	31 December 2025
Estimated completion	31 December 2025
Sites	1 location across Canada

Drugs / interventions tested

Cognitive Training
Aerobic and resistance exercises
Stretching and Toning

Conditions studied

Aging — all drugs for Aging →
Cardiovascular Risk Factor — all drugs for Cardiovascular Risk Factor →

Sponsor

Louis Bherer

Who can join

60 and older, any sex, with Aging or Cardiovascular Risk Factor. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The ACTIONcardioRisk trial is designed to investigate the effect of aerobic and progressive resistance training exercises combined with cognitive training, on neurocognitive functioning of sedentary older adults with and without cardiovascular risk factors.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Investigating the effects of a randomized, double-blinded aerobic, resistance, and cognitive training clinical trial on neurocognitive function in older adults with cardiovascular risk factors: the ACTIONcardioRisk protocol.
Bherer L, Vrinceanu T, Dupuy EG, Gayda M, et al · · 2025 · PMID 40625372 · DOI 10.3389/fnagi.2025.1605128

Verify or expand the search:

Other trials of Cognitive Training

Trials testing the same drug.

NCT07085494 — Neurofeedback and Cognitive Training for PBTS · NA · enrolling by invitation
NCT06961916 — Enhancing Brain Connectivity in Schizophrenia Through Neuromodulation (Study 2) · NA · recruiting
NCT07213232 — Dual-Task Balance and Gait Training Combined With Cognitive Training in Parkinson's Patients · NA · enrolling by invitation
NCT06867016 — Effects of Bidomain Cognitive and Aerobic Training on Cognitive Functioning in Mild Cognitive Impairment. · NA · completed
NCT06601933 — Cognitive Training and Neuroplasticity in Mild Cognitive Impairment: COGIT-2 Trial · Phase 2 · recruiting

Other recruiting trials for Aging

Currently open trials in the same condition.

NCT02831335 — Technical Development of Multi-Parametric Renocerebral MRI · recruiting
NCT07099053 — Amyloid PET Imaging in the Baltimore Longitudinal Study of Aging · recruiting
NCT07504068 — Effects of Physical Exercise and a Nutritional Supplement on Body Composition, Metabolic Function, and Overall Health in · NA · recruiting
NCT07525453 — Effects of Three Different Exercise Programs on Dynamic Balance in Community-Dwelling Older Adults · NA · recruiting
NCT07500727 — Skeletal Muscle Aging and Responsiveness in Aged People With MS · NA · recruiting

Other Louis Bherer trials

Trials by the same sponsor.

NCT06130358 — Investigating the Effects of a Museum Intervention on the Psychological and Cardiac Health of Older Adults · NA · unknown
NCT05035628 — Cardiopulmonary Rehabilitation in Long COVID-19 Patients With Persistent Breathlessness and Fatigue · NA · completed
NCT04635462 — The Cognitive and spOrt Virtual EPIC Training Study · NA · completed
NCT04806841 — Effect of a Motivational Intervention on Exercise Adherence After Cardiac Rehabilitation · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04962061 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Louis Bherer
Last refreshed: 6 February 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04962061.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing