NCT04279548 (PSI-DBS) is a NA clinical trial of Deep Brain Stimulation in Neuropathic Pain, sponsored by University of Sao Paulo.

Who is sponsoring NCT04279548?

NCT04279548 is sponsored by University of Sao Paulo.

What drugs are being tested in NCT04279548?

Interventions in NCT04279548: Deep Brain Stimulation.

What condition does NCT04279548 study?

NCT04279548 studies Neuropathic Pain, Neuropathy;Peripheral.

Is NCT04279548 still recruiting?

NCT04279548 is currently completed. Last updated 28 January 2022.

Last reviewed 2022-01-28 · How we verify

NCT04279548: PSI-DBS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Posterior-superior Insula Deep Brain Stimulation in Refractory Peripheral Neuropathic Pain Patients

Completed NA Last updated 28 January 2022

What this trial tests

NA trial testing Deep Brain Stimulation in Neuropathic Pain in 10 participants. Completed in 1 July 2021.

Timeline

1 January 2018

Primary endpoint
1 October 2019

1 July 2021

Quick facts

Lead sponsor	University of Sao Paulo
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	quadruple
Primary purpose	treatment
Enrollment	10
Start date	1 January 2018
Primary completion	1 October 2019
Estimated completion	1 July 2021
Sites	1 location across Brazil

Drugs / interventions tested

Deep Brain Stimulation

Conditions studied

Neuropathic Pain — all drugs for Neuropathic Pain →
Neuropathy;Peripheral — all drugs for Neuropathy;Peripheral →

Sponsor

University of Sao Paulo

Who can join

Adults 21 to 70, any sex, with Neuropathic Pain or Neuropathy;Peripheral. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study evaluates the long term pain relief after deep brain stimulation on posterior-superior insula (PSI) in patients with refractory peripheral neuropathic pain who responded to real but not to sham non-invasive stimulation by deep repetitive transcranial magnetic stimulation - PSI-drTMS.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Deep Brain Stimulation for the Management of Refractory Neurological Disorders: A Comprehensive Review.
Rissardo JP, Vora NM, Tariq I, Mujtaba A, et al · · 2023 · cited 17× · PMID 38004040 · DOI 10.3390/medicina59111991
Insula Deep Brain Stimulation for Neuropathic Pain: A Cross-Over, Randomized, Sham-Controlled Trial.
Dongyang L, Cunha PHM, Lapa JDS, Kubota GT, et al · · 2026 · cited 1× · PMID 40824225 · DOI 10.1016/j.neurom.2025.07.001

Verify or expand the search:

Other trials of Deep Brain Stimulation

Trials testing the same drug.

NCT06924086 — The Children's Adaptive Deep Brain Stimulation for Epilepsy Trial · NA · recruiting
NCT07369401 — Deep Brain Stimulation of the Nucleus Accumbens and Anterior Limb of the Internal Capsule in the Treatment of Refractory · NA · not yet recruiting
NCT07214467 — Individualized Adaptive Deep Brain Stimulation in Opioid Use Disorder · NA · recruiting
NCT06991335 — VC/VS for Apathy in PD · NA · not yet recruiting
NCT07049003 — Deep Brain Stimulation of the Deep Cerebellar Nuclei for Refractory Tremor · Phase 1 · recruiting

Other recruiting trials for Neuropathic Pain

Currently open trials in the same condition.

NCT07493213 — USG-Guided Shoulder Injections in Frozen Shoulder · NA · recruiting
NCT07493226 — Efficacy of Chemically Distinct Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Pain Phenotypes in Adhesive Capsulitis · NA · recruiting
NCT06398847 — Virtual Reality (VR) Self-Hypnosis Software · NA · recruiting
NCT07487610 — Relationship Between Neuropathic Pain and Geriatric Assessment Parameters in Patients Aged 80 Years and Older · recruiting
NCT07436806 — SPS Block vs. Surgical Intercostal Block for Chronic Pain After Thoracoscopic Surgery · NA · recruiting

Other University of Sao Paulo trials

Trials by the same sponsor.

NCT07463859 — Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabet · NA · recruiting
NCT07522554 — Lavender and Lemongrass Aromatherapy for Pain and Anxiety in Labor: A Randomized Trial · NA · active not recruiting
NCT07479940 — Obesity and Aging: Impacts of Nutritional Counseling and Physical Exercise on Telomeres and Senescence Parameters · NA · active not recruiting
NCT07445178 — Piecemeal Resection and Advanced Histology Independently Predict Local Recurrence After Colorectal Snare-based Endoscopi · completed
NCT07170007 — Physiotherapeutic Protocol Compared to Usual Care in the Treatment of Primiparas After Perineal Trauma · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04279548 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Sao Paulo
Last refreshed: 28 January 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04279548.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing