NCT04271241 is a NA clinical trial of Passive stretching (PS) training in Vasodilation, sponsored by University of Milan.

Who is sponsoring NCT04271241?

NCT04271241 is sponsored by University of Milan.

What drugs are being tested in NCT04271241?

Interventions in NCT04271241: Passive stretching (PS) training.

What condition does NCT04271241 study?

NCT04271241 studies Vasodilation, Vasoconstriction, Stretch, Sympathetic; Imbalance.

Is NCT04271241 still recruiting?

NCT04271241 is currently completed. Last updated 17 February 2020.

Last reviewed 2020-02-17 · How we verify

NCT04271241

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Vascular Function Improvements After Chronic Passive Stretching

Completed NA Last updated 17 February 2020

What this trial tests

NA trial testing Passive stretching (PS) training in Vasodilation in 39 participants. Completed in 7 February 2020.

Timeline

7 January 2019

Primary endpoint
7 January 2020

7 February 2020

Quick facts

Lead sponsor	University of Milan
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	39
Start date	7 January 2019
Primary completion	7 January 2020
Estimated completion	7 February 2020
Sites	1 location across Italy

Drugs / interventions tested

Passive stretching (PS) training

Conditions studied

Vasodilation — all drugs for Vasodilation →
Vasoconstriction — all drugs for Vasoconstriction →
Stretch — all drugs for Stretch →
Sympathetic; Imbalance — all drugs for Sympathetic; Imbalance →

Sponsor

University of Milan

Who can join

18 and older, any sex, with Vasodilation or Vasoconstriction. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Acutely, during different bouts of passive stretching (PS), blood flow (Q ̇) and shear rate ( ) in the feeding artery of the stretched muscles increases during the first two elongations and then it reduces during the following bouts. This hyperemic response during the first two elongations is mediated by the local release of vasoactive molecules (e.g. nitric oxide, NO). This phenomenon disappears during the following elongations due to the NO and other vasoactive molecule depletion. The relaxation phase between stretching bouts, instead, is always characterized by hyperemia as results of stretch-induced peripheral resistances decrease. Whether chronic PS administration may influence vascular function is still a matter of investigation. The hypothesis is that repetitive PS-induced Q ̇ and changes may be an enough stimulus to provoke increments in NO bioavailability, thus improving vasomotor response.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other recruiting trials for Vasodilation

Currently open trials in the same condition.

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NCT05997732 — Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences · Phase 4 · recruiting
NCT06454084 — Investigation of Endothelium-dependent Vasodilation in Human Gingiva · NA · active not recruiting
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Other University of Milan trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04271241 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Milan
Last refreshed: 17 February 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04271241.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing