Last reviewed · How we verify
NCT07273123
The Effect of Prolonged Sugar-Free Chewing Gum Mastication on Self-Reported Fatigue Levels and Changes of Static and Dynamic Surface Electromyography Parameters in Young Individuals With and Without Temporomandibular Joint Disorders.
trial testing Mastication of sugar-free chewing gum in Temporomandibular Joint Disorder in 30 participants. Currently enrolling.
30 July 2026
Quick facts
| Lead sponsor | University of Milan |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 30 |
| Start date | 1 December 2025 |
| Primary completion | 30 July 2026 |
| Estimated completion | 30 July 2026 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Mastication of sugar-free chewing gum
Conditions studied
- Temporomandibular Joint Disorder — all drugs for Temporomandibular Joint Disorder →
Sponsor
University of Milan
Who can join
Adults 19 to 35, any sex, with Temporomandibular Joint Disorder. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This case-control study investigates fatigue induced by prolonged gum mastication in individuals with temporomandibular disorders (TMD). The study addresses two primary questions: How does self-reported fatigue, measured with a visual analogue scale (VAS), change during sustained chewing? How do static and dynamic surface electromyographic (sEMG) parameters evolve over the same period? Participants with TMD will be compared with healthy controls to determine group differences in perceived fatigue and EMG responses. All participants will undergo baseline EMG assessment, then chew sugar-free gum continuously for 3 minutes, alternating sides without rest. After each 3-minute interval, static and dynamic EMG recordings will be obtained and participants will rate their fatigue on the VAS. This cycle may be repeated up to six times (maximum 18 minutes). Participants are free to stop chewing at any time if fatigue becomes intolerable.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07273123
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Temporomandibular Joint Disorder
Currently open trials in the same condition.
- NCT06874868 — Salivary Cortisol As a Biomarker in Patients with Temporomandibular Disorder · recruiting
Other University of Milan trials
Trials by the same sponsor.
- NCT07476417 — Oral Health, Dento-facial Condition and OHRQoL in Subjects With Mowat-Wilson Syndrome: an Epidemiologic Study. · not yet recruiting
- NCT07259902 — FMRI Study on DC/TMD Patients · NA · not yet recruiting
- NCT07262437 — Targeting Immunosuppressive Treatment for Non-infectious Uveitis Using Aqueous Humor Cytokine Profiles · NA · active not recruiting
- NCT07312305 — Small Airways Disease Functional Assessment in Idiopathic Pulmonary Fibrosis (SWIFT-IPF) · recruiting
- NCT07000838 — Efficacy of Corrective Rubber Insoles in Healthcare Professionals With Foot Overpronation · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07273123 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Milan
- Last refreshed: 9 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07273123.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing