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NCT04204304
Relationship Between Serum Vitamin D Levels and Musculoskeletal Adverse Effects in Patients Using Isotretinoin
NA trial testing Isotretinoin in Musculoskeletal Disease Other in 177 participants. Completed in 1 October 2019.
15 August 2019
Quick facts
| Lead sponsor | Ankara Training and Research Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | screening |
| Enrollment | 177 |
| Start date | 15 March 2019 |
| Primary completion | 15 August 2019 |
| Estimated completion | 1 October 2019 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Isotretinoin (ISOTRETINOIN) — full drug profile →
Conditions studied
- Musculoskeletal Disease Other — all drugs for Musculoskeletal Disease Other →
- Isotretinoin Adverse Reaction — all drugs for Isotretinoin Adverse Reaction →
- Vitamin D Deficiency — all drugs for Vitamin D Deficiency →
Sponsor
Ankara Training and Research Hospital
Who can join
18 and older, any sex, with Musculoskeletal Disease Other or Isotretinoin Adverse Reaction. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Isotretinoin (ISO) has been used in the treatment of patients with severe acne vulgaris (AV) that is resistant to standard therapy with systemic antibiotics and topical agents, over the last few decades. There are various side effects of ISO in the skeletal system. This study investigate the relationship between ISO-induced musculoskeletal adverse effects and serum 25 hydroxy (OH) vitamin D levels in patients with acne vulgaris.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effect of Serum 25 Hydroxy Vitamin D Level on Isotretinoin-Induced Musculoskeletal Symptoms: A Cross-Sectional Study.
Mülkoğlu C, Karaosmanoğlu N. · · 2020 · cited 1× · PMID 32042004 · DOI 10.1038/s41598-020-59167-0
Verify or expand the search:
- PubMed search for NCT04204304
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Isotretinoin
Trials testing the same drug.
- NCT06698263 — 13-cis Retinoic Acid (Isotretinoin) and Sperm Production · Phase 4 · not yet recruiting
- NCT07054398 — Assessment of Serum Catestatin Level in Acne Vulgaris Patients · NA · recruiting
- NCT06172296 — Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed · Phase 3 · recruiting
- NCT05869188 — Effect of Systemic Isotretinoin on Serum Irisin Level in Acne Vulgaris Patients · NA · completed
- NCT06201624 — Oral Isotretinoin in Melasma a Randomized Controlled Trial · Phase 1 · unknown
Other Ankara Training and Research Hospital trials
Trials by the same sponsor.
- NCT07150455 — Evaluation of Myocardial Function by Global Longitudinal Strain (GLS) Measurement in 2D Echocardiography of Patients Wit · completed
- NCT07467421 — "Effectiveness of Physical Therapy Added to Transforaminal Injection in Lumbar Radicular Pain" · NA · completed
- NCT07143084 — Investigation of the Relationship Between Nutritional Status Assessment and Frailty in Critical Care Patients · enrolling by invitation
- NCT07310667 — Assessing the Relationship Between Frailty and Skeletal Muscle Thickness in Critically Ill Patients · enrolling by invitation
- NCT06946030 — Pseudoexfoliation and Carpal Tunnel Study · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04204304 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ankara Training and Research Hospital
- Last refreshed: 18 December 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04204304.
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