Last reviewed · How we verify
NCT04179578: PEH2
The Value of Lateral Release in Reconstruction of the Diaphragmatic Hiatus Hernia
NA trial testing Crura plastic in Paraesophageal Hernia in 70 participants. Participants enrolled and being followed up; not accepting new ones.
31 December 2026
Quick facts
| Lead sponsor | Karolinska Institutet |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 70 |
| Start date | 16 July 2019 |
| Primary completion | 31 December 2026 |
| Estimated completion | 31 December 2026 |
| Sites | 1 location across Sweden |
Drugs / interventions tested
- Crura plastic
Conditions studied
- Paraesophageal Hernia — all drugs for Paraesophageal Hernia →
Sponsor
Karolinska Institutet
Who can join
18 and older, any sex, with Paraesophageal Hernia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Patients scheduled for surgery for primary paraesophageal herniation are randomized to either conventional suturing of the crura or with the addition of lateral release.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The value of "diaphragmatic relaxing incision" for the durability of the crural repair in patients with paraesophageal hernia: a double blind randomized clinical trial.
Tsoposidis A, Thorell A, Axelsson H, Reuterwall Hansson M, et al · · 2023 · cited 2× · PMID 38026477 · DOI 10.3389/fsurg.2023.1265370
Verify or expand the search:
- PubMed search for NCT04179578
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Paraesophageal Hernia
Currently open trials in the same condition.
- NCT06725433 — Nissen Versus Dor Hiatal Hernia Repair · NA · recruiting
- NCT06107634 — Gastropexy in the Repair of Patients with Paraesophageal Hernias · NA · recruiting
- NCT05201508 — Sutures Versus Polyglactin Mesh in Hiatal Hernia Repair · NA · recruiting
Other Karolinska Institutet trials
Trials by the same sponsor.
- NCT06359262 — Evaluating the Hope@School Prevention Program · NA · not yet recruiting
- NCT07289490 — Bilateral vs Unilateral Inguinal Hernia Repairs With an Asymptomatic Inguinal Hernia in Bilateral Hernias · NA · not yet recruiting
- NCT06894264 — Emotion Processing and Regulation in People With Intellectual Disability · NA · not yet recruiting
- NCT07494266 — Safety of a Healthy Plant-based Diet With Higher Potassium Content, Compared to a Healthy Plant-based Diet With Limited · NA · not yet recruiting
- NCT07442032 — Cardiovascular Phenotypes in Sepsis · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04179578 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Karolinska Institutet
- Last refreshed: 22 October 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04179578.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing