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NCT06725433: NiDor
Nissen Versus Dor Hiatal Hernia Repair
NA trial testing Nissen fundoplication in Hiatal Hernia in 150 participants. Currently enrolling.
30 January 2030
Quick facts
| Lead sponsor | Kuopio University Hospital |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 150 |
| Start date | 7 February 2025 |
| Primary completion | 30 January 2030 |
| Estimated completion | 30 January 2030 |
| Sites | 1 location across Finland |
Drugs / interventions tested
- Nissen fundoplication
- Dor fundoplication
Conditions studied
- Hiatal Hernia — all drugs for Hiatal Hernia →
- Paraesophageal Hernia — all drugs for Paraesophageal Hernia →
- Recurrence — all drugs for Recurrence →
Sponsor
Kuopio University Hospital
Who can join
18 and older, any sex, with Hiatal Hernia or Paraesophageal Hernia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Hiatal hernia can present with a wide range of symptoms. An usual surgical repair technique usually includes Nissen fundoplication, while other procedures are less frequently employed. However, recurrence and reoperation rates remain high. This randomized controlled trial aims to compare the efficacy of Nissen and Dor fundoplication in preventing hiatal hernia recurrence and reducing the risk of reoperation Participants undergoing minimally invasive hiatal hernia repair will be randomly assigned to either Nissen or Dor fundoplication. Postoperatively at 12 months, anatomical recurrence rates based on computed tomography scans and symptomatic recurrence rates, anti-reflux medication use, GERD-related quality of life, and dysphagia symptoms will be assessed. A subsequent long-term follow-up study will conducted afterwards utilizing national registry data to evaluate reoperation rates and anti-reflux medication use
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06725433
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Nissen fundoplication
Trials testing the same drug.
- NCT07004400 — A Blinded Randomized Clinical Study of RefluxStop™ Compared With Nissen Fundoplication in the Treatment of GERD · NA · not yet recruiting
- NCT05870163 — Post-Market Registry for the Evaluation of RefluxStop in GERD Treatment · recruiting
- NCT05068089 — Health, Economic Analysis and Clinical Aspects of Patients With Neurological Disabilities in Enteral Nutrition With Dedi · unknown
- NCT01265550 — A Randomized Trial of Medical and Surgical Treatments for Patients With GERD Symptoms That Are Refractory to Proton Pump · Phase 3 · completed
Other recruiting trials for Hiatal Hernia
Currently open trials in the same condition.
- NCT07070115 — Evaluating Clinical Hiatal Hernia Outcomes Using OviTex® · NA · recruiting
- NCT06884800 — Laparoscopic Toupet's Fundoplication: Is it Proper Solution of Radiological Negative, Endoscopically Positive Hiatal Her · NA · recruiting
- NCT05953428 — Reducing Postoperative Opioids in Patients Undergoing Laparoscopic Hiatal Hernia · NA · recruiting
- NCT05201508 — Sutures Versus Polyglactin Mesh in Hiatal Hernia Repair · NA · recruiting
Other Kuopio University Hospital trials
Trials by the same sponsor.
- NCT06495268 — Healthy heaAring for Healthy Ageing: Data-driven Hearing Rehabilitation Intervention to Promote Healthy Hearing · NA · active not recruiting
- NCT06740097 — Feasibility of Aspirate Tissue Monitoring in Neuro-oncological Surgery · NA · recruiting
- NCT06460363 — Transcranial Alternating Current Stimulation on Patients with Delirium and Critical Illness (DeliTACS) · NA · recruiting
- NCT05863624 — Open and Endoscopic Technique in Female Inguinal Hernia Repair. FemaleHernia · NA · not yet recruiting
- NCT06321133 — High Flow Nasal Cannula Weaning in Acute Bronchiolitis · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06725433 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Kuopio University Hospital
- Last refreshed: 19 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06725433.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing