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Effect of Injectable Platelet-Rich Fibrin (i-PRF) in Initial Treatment of Chronic Periodontitis
Phase 4 trial testing SRP + Injectable Platelet-Rich Fibrin in Periodontitis in 32 participants. Completed in 9 July 2020.
| Lead sponsor | University of Belgrade |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 32 |
| Start date | 2 October 2019 |
| Primary completion | 29 June 2020 |
| Estimated completion | 9 July 2020 |
| Sites | 1 location across Serbia |
University of Belgrade
Adults 20 to 65, any sex, with Periodontitis. Patients with the condition only — healthy volunteers not accepted.
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
assessment of periodontal pocket depth by probing, mean value of periodontal pockets on one side of the jaw
| Group | Value | 95% CI |
|---|---|---|
| SRP + Injectable Platelet-Rich Fibrin | 3.735 | ± 0.863 |
| SRP + Placebo | 3.696 | ± 0.851 |
assessment of periodontal pocket depth by probing, mean value of periodontal pockets on one side of the jaw
| Group | Value | 95% CI |
|---|---|---|
| SRP + Injectable Platelet-Rich Fibrin | 2.398 | ± 0.792 |
| SRP + Placebo | 2.876 | ± 0.804 |
assessment of periodontal pocket depth by probing, mean value of periodontal pockets on one side of the jaw
| Group | Value | 95% CI |
|---|---|---|
| SRP + Injectable Platelet-Rich Fibrin | 1.990 | ± 0.640 |
| SRP + Placebo | 2.567 | ± 0.701 |
assessment of periodontal pocket depth by probing mean value of one side of the jaw
| Group | Value | 95% CI |
|---|---|---|
| SRP + Injectable Platelet-Rich Fibrin | 1.778 | ± 0.542 |
| SRP + Placebo | 2.409 | ± 0.640 |
assessment of level of gingival margin-LGM by probing, i.e.distance between cementoenamel junction and gingival margin (the most coronal point of the gingiva); mean value of one side of the jaw
| Group | Value | 95% CI |
|---|---|---|
| SRP + Injectable Platelet-Rich Fibrin | 1.737 | ± 0.567 |
| SRP + Placebo | 1.787 | ± 0.589 |
assessment of level of gingival margin-LGM by probing, i.e.distance between cementoenamel junction and gingival margin (the most coronal point of the gingiva); mean value of one side of the jaw
| Group | Value | 95% CI |
|---|---|---|
| SRP + Injectable Platelet-Rich Fibrin | 0.948 | ± 0.573 |
| SRP + Placebo | 1.150 | ± 0.462 |
assessment of level of gingival margin-LGM by probing, i.e. distance between cementoenamel junction and gingival margin (the most coronal point of the gingiva); mean value of one side of the jaw
| Group | Value | 95% CI |
|---|---|---|
| SRP + Injectable Platelet-Rich Fibrin | 0.782 | ± 0.580 |
| SRP + Placebo | 0.877 | ± 0.533 |
assessment of level of gingival margin-LGM by probing, distance between cementoenamel junction and gingival margin (the most coronal point of the gingiva) after 6 months
| Group | Value | 95% CI |
|---|---|---|
| SRP + Injectable Platelet-Rich Fibrin | 0.808 | ± 0.518 |
| SRP + Placebo | 0.794 | ± 0.457 |
assessment of clinical attachment level- CAL by probing
| Group | Value | 95% CI |
|---|---|---|
| SRP + Injectable Platelet-Rich Fibrin | 2.009 | ± 0.724 |
| SRP + Placebo | 2.018 | ± 0.715 |
assessment of clinical attachment level- CAL by probing, mean value of one side of the jaw
| Group | Value | 95% CI |
|---|---|---|
| SRP + Injectable Platelet-Rich Fibrin | 1.453 | ± 0.643 |
| SRP + Placebo | 1.755 | ± 0.654 |
assessment of clinical attachment level- CAL by probing, mean value of one side of the jaw
| Group | Value | 95% CI |
|---|---|---|
| SRP + Injectable Platelet-Rich Fibrin | 1.237 | ± 0.610 |
| SRP + Placebo | 1.619 | ± 0.618 |
assessment of clinical attachment level- CAL by probing, mean value of one side of the jaw
| Group | Value | 95% CI |
|---|---|---|
| SRP + Injectable Platelet-Rich Fibrin | 1.226 | ± 0.580 |
| SRP + Placebo | 1.585 | ± 0.619 |
Current treatments of periodontitis have limited efficacy since they fail to suppress microorganisms satisfactorily over time. The aim of present study was to investigate whether there are differences between initial treatment of chronic periodontitis (SRP) and SRP in conjunction with injectable platelet-rich fibrin (i-PRF) application.
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
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