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SRP + Injectable Platelet-Rich Fibrin
SRP (Scaling and Root Planing) combined with Injectable Platelet-Rich Fibrin promotes periodontal tissue regeneration and healing by delivering concentrated growth factors and platelets to diseased periodontal sites.
SRP (Scaling and Root Planing) combined with Injectable Platelet-Rich Fibrin promotes periodontal tissue regeneration and healing by delivering concentrated growth factors and platelets to diseased periodontal sites. Used for Chronic periodontitis with periodontal bone loss, Periodontal defects requiring tissue regeneration.
At a glance
| Generic name | SRP + Injectable Platelet-Rich Fibrin |
|---|---|
| Also known as | SRP + i-PRF |
| Sponsor | University of Belgrade |
| Drug class | Regenerative medicine / Periodontal therapy |
| Modality | Small molecule |
| Therapeutic area | Dentistry / Periodontics |
| Phase | FDA-approved |
Mechanism of action
Scaling and root planing mechanically removes bacterial biofilm and calculus from tooth surfaces and root canals. Injectable Platelet-Rich Fibrin (PRF) is an autologous biomaterial derived from the patient's own blood that concentrates platelets, leukocytes, and fibrin, releasing growth factors (PDGF, VEGF, TGF-β) that stimulate tissue regeneration, angiogenesis, and bone formation in the periodontal defect.
Approved indications
- Chronic periodontitis with periodontal bone loss
- Periodontal defects requiring tissue regeneration
Common side effects
- Infection at injection site
- Mild inflammation
- Temporary discomfort
Key clinical trials
- Injectable PRF in Non-Surgical Periodontal Treatment (NA)
- Melatonin Loaded in Injectable Platelet-Rich Fibrin in the Management Periodontitis (PHASE4)
- Evaluation of Repeated Injectable PRF Following SRP in Patients With Periodontitis (NA)
- The Effect of Locally Dilvered Ciprofloxacine Loaded Injectable Platelet-rich Fibrin as an Adjunct to Non-surgical Periodontal Therapy on the Gingival Crevicular Level of Interleukin 6 (NA)
- Use of Injectable Extended Platelet-Rich Fibrin as a Local Drug Delivery in the Treatment of Stage II Periodontitis Patients (NA)
- Comparison Between the Efficacy of Albumin Versus Hyaluronic Acid Scaffold in Combination With Concentrated Growth Factors as an Adjunct to Non-surgical Treatment of Periodontitis (NA)
- The Effectiveness of Root Planing and Injectable Platelet-Rich Fibrin in Smoking Patients With Periodontitis (NA)
- Evaluation of the Influence of PRF (Platelet-rich Fibrin) on the Clinical Parameters and the Concentration of Selected Inflammation Mediators in GCF (Gingival Crevice Fluid) of Patients With Periodontitis (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- SRP + Injectable Platelet-Rich Fibrin CI brief — competitive landscape report
- SRP + Injectable Platelet-Rich Fibrin updates RSS · CI watch RSS
- University of Belgrade portfolio CI