{"id":"srp-injectable-platelet-rich-fibrin","safety":{"commonSideEffects":[{"rate":null,"effect":"Infection at injection site"},{"rate":null,"effect":"Mild inflammation"},{"rate":null,"effect":"Temporary discomfort"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Scaling and root planing mechanically removes bacterial biofilm and calculus from tooth surfaces and root canals. Injectable Platelet-Rich Fibrin (PRF) is an autologous biomaterial derived from the patient's own blood that concentrates platelets, leukocytes, and fibrin, releasing growth factors (PDGF, VEGF, TGF-β) that stimulate tissue regeneration, angiogenesis, and bone formation in the periodontal defect.","oneSentence":"SRP (Scaling and Root Planing) combined with Injectable Platelet-Rich Fibrin promotes periodontal tissue regeneration and healing by delivering concentrated growth factors and platelets to diseased periodontal sites.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:08:59.870Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic periodontitis with periodontal bone loss"},{"name":"Periodontal defects requiring tissue regeneration"}]},"trialDetails":[{"nctId":"NCT07375004","phase":"NA","title":"Injectable PRF in Non-Surgical Periodontal Treatment","status":"ACTIVE_NOT_RECRUITING","sponsor":"Al-Mustansiriyah University","startDate":"2025-11-06","conditions":"Periodontitis, Periodontal Pocket, Alveolar Bone Loss","enrollment":13},{"nctId":"NCT07316582","phase":"PHASE4","title":"Melatonin Loaded in Injectable Platelet-Rich Fibrin in the Management Periodontitis","status":"ENROLLING_BY_INVITATION","sponsor":"Al-Azhar University","startDate":"2025-11-01","conditions":"Periodontitis Stage II","enrollment":60},{"nctId":"NCT07029035","phase":"NA","title":"Evaluation of Repeated Injectable PRF Following SRP in Patients With Periodontitis","status":"COMPLETED","sponsor":"Saglik Bilimleri Universitesi","startDate":"2023-12-01","conditions":"Periodontitis Stage III","enrollment":20},{"nctId":"NCT06968286","phase":"NA","title":"The Effect of Locally Dilvered Ciprofloxacine Loaded Injectable Platelet-rich Fibrin as an Adjunct to Non-surgical Periodontal Therapy on the Gingival Crevicular Level of Interleukin 6","status":"COMPLETED","sponsor":"Suez Canal University","startDate":"2025-01-01","conditions":"Periodontitis Stage II","enrollment":60},{"nctId":"NCT07080294","phase":"NA","title":"Use of Injectable Extended Platelet-Rich Fibrin as a Local Drug Delivery in the Treatment of Stage II Periodontitis Patients","status":"COMPLETED","sponsor":"Mansoura University","startDate":"2024-04-17","conditions":"Periodontitis Stage II, Gingival Pocket","enrollment":45},{"nctId":"NCT07081230","phase":"NA","title":"Comparison Between the Efficacy of Albumin Versus Hyaluronic Acid Scaffold in Combination With Concentrated Growth Factors as an Adjunct to Non-surgical Treatment of Periodontitis","status":"RECRUITING","sponsor":"husain abduljalil alam","startDate":"2025-07-07","conditions":"Periodontitis","enrollment":30},{"nctId":"NCT07049549","phase":"NA","title":"The Effectiveness of Root Planing and Injectable Platelet-Rich Fibrin in Smoking Patients With Periodontitis","status":"COMPLETED","sponsor":"Izmir Katip Celebi University","startDate":"2019-09-01","conditions":"Periodontal Healing, Periodontitis, i-PRF","enrollment":25},{"nctId":"NCT06920849","phase":"NA","title":"Evaluation of the Influence of PRF (Platelet-rich Fibrin) on the Clinical Parameters and the Concentration of Selected Inflammation Mediators in GCF (Gingival Crevice Fluid) of Patients With Periodontitis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Medical University of Bialystok","startDate":"2022-04-01","conditions":"Periodontal Disease, Periodontitis","enrollment":40},{"nctId":"NCT05768243","phase":"PHASE4","title":"Hyaluronic Acid Versus Red Injectable Platelet Rich Fibrin in Treatment of Periodontitis","status":"COMPLETED","sponsor":"Beirut Arab University","startDate":"2021-03-01","conditions":"Periodontitis Chronic Generalized Severe","enrollment":75},{"nctId":"NCT05753631","phase":"","title":"Effects of i-PRF on Non-surgical Periodontal Treatment","status":"COMPLETED","sponsor":"Pamukkale University","startDate":"2022-02-02","conditions":"Platelet-Rich Fibrin","enrollment":24},{"nctId":"NCT04178590","phase":"PHASE4","title":"Effect of Injectable Platelet-Rich Fibrin (i-PRF) in Initial Treatment of Chronic Periodontitis","status":"COMPLETED","sponsor":"University of Belgrade","startDate":"2019-10-02","conditions":"Periodontitis","enrollment":32}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":10,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["SRP + i-PRF"],"phase":"marketed","status":"active","brandName":"SRP + Injectable Platelet-Rich Fibrin","genericName":"SRP + Injectable Platelet-Rich Fibrin","companyName":"University of Belgrade","companyId":"university-of-belgrade","modality":"Small molecule","firstApprovalDate":"","aiSummary":"SRP (Scaling and Root Planing) combined with Injectable Platelet-Rich Fibrin promotes periodontal tissue regeneration and healing by delivering concentrated growth factors and platelets to diseased periodontal sites. Used for Chronic periodontitis with periodontal bone loss, Periodontal defects requiring tissue regeneration.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}