NCT04145492 is a Phase 2, PHASE3 clinical trial of Vitamin K2 in End Stage Renal Disease, sponsored by Ain Shams University.

Who is sponsoring NCT04145492?

NCT04145492 is sponsored by Ain Shams University.

What drugs are being tested in NCT04145492?

Interventions in NCT04145492: Vitamin K2, Cholecalciferol (inactive vitamin D), Vitamin K2 and Cholecalciferol.

What condition does NCT04145492 study?

NCT04145492 studies End Stage Renal Disease.

Is NCT04145492 still recruiting?

NCT04145492 is currently status unknown. Last updated 30 October 2019.

Last reviewed 2019-10-30 · How we verify

NCT04145492

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Vitamin K 2 on Vascular Calcification in Hemodialysis Patients

Status unknown Phase 2, PHASE3 Last updated 30 October 2019

What this trial tests

Phase 2, PHASE3 trial testing Vitamin K2 in End Stage Renal Disease in 60 participants. Status unknown.

Timeline

1 September 2019

Primary endpoint
1 January 2020

1 February 2020

Quick facts

Lead sponsor	Ain Shams University
Phase	Phase 2, PHASE3
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	60
Start date	1 September 2019
Primary completion	1 January 2020
Estimated completion	1 February 2020
Sites	1 location across Egypt

Drugs / interventions tested

Vitamin K2 — full drug profile →
Cholecalciferol (inactive vitamin D) — full drug profile →
Vitamin K2 and Cholecalciferol — full drug profile →

Conditions studied

End Stage Renal Disease — all drugs for End Stage Renal Disease →

Sponsor

Ain Shams University

Who can join

Adults 6 to 18, any sex, with End Stage Renal Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of this study is to assess the effect of supplementation of vitamin K2 (menaquinone, MK-7) and cholecalciferol (inactive vitamin D) on circulating levels of calcification regulators and to assess their safety in pediatric patients on regular hemodialysis patients.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Molecular Pathways and Roles for Vitamin K2-7 as a Health-Beneficial Nutraceutical: Challenges and Opportunities.
Jadhav N, Ajgaonkar S, Saha P, Gurav P, et al · · 2022 · cited 51× · PMID 35774605 · DOI 10.3389/fphar.2022.896920
Effects of vitamin K supplementation on vascular calcification in chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials.
Geng C, Huang L, Pu L, Feng Y. · · 2022 · cited 8× · PMID 36704782 · DOI 10.3389/fnut.2022.1001826
The Role of Vitamin K in CKD-MBD.
Fusaro M, Tondolo F, Gasperoni L, Tripepi G, et al · · 2022 · cited 8× · PMID 35132525 · DOI 10.1007/s11914-022-00716-z
The impact of vitamin K2 and native vitamin D supplementation on vascular calcification in pediatric patients on regular hemodialysis. A randomized controlled trial.
El Borolossy R, El-Farsy MS. · · 2022 · cited 8× · PMID 34845313 · DOI 10.1038/s41430-021-01050-w

Verify or expand the search:

Other trials of Vitamin K2

Trials testing the same drug.

NCT06817512 — Ischemic Stroke Nutrition Intervention Study · NA · active not recruiting
NCT05995522 — Effect of Vitamin K2 Over Osteocalcin, Leptin, Cytokines, and Cardiovascular Risk in Young Adults With Overweight and Ob · NA · completed
NCT05675163 — Antioxidant and Immune Effects of Vitamin K2 · NA · completed
NCT05547750 — Effect of Vitamin K2 in the Treatment of Nocturnal Leg Cramps in Older Population · NA · completed
NCT05161975 — Vitamin K2 Supplements for Muscle Recovery · NA · unknown

Other recruiting trials for End Stage Renal Disease

Currently open trials in the same condition.

NCT06257134 — Impact on Quality of Life of Symptoms Routine E-monitoring Among Dialysis Patients. · NA · recruiting
NCT06310161 — Light Therapy in End Stage Kidney Disease · NA · recruiting
NCT07360938 — Drug Interaction Potential of Pro-Inflammatory Conditions · recruiting
NCT06422871 — PReSeRVE-HD: Observational Study of the Merit HeRO® Graft and Super HeRO® in Patients on Hemodialysis · recruiting
NCT06861816 — Ventilatory Functions and Physical Intolerance in ESRD Adolescents: Response to Program of Walking With Dogs · NA · recruiting

Other Ain Shams University trials

Trials by the same sponsor.

NCT07435493 — Fentanyl Versus Opioid Free Multimodal Analgesia for Perioperative Pain Control in Children With Mild to Moderate Obstru · NA · not yet recruiting
NCT07482540 — Role of Dexmedatomidine Drug in Prevention of Atrial Fibrillations Post Mitral Valve Surgery · NA · not yet recruiting
NCT07531030 — Posterior Pericapsular Deep Gluteal Block Combined With Pericapsular Nerve Group and Lateral Femoral Cutaneous Nerve Blo · NA · not yet recruiting
NCT06839027 — Arterial to Central co2gap in Relation to Outcome After Cardiopulmonary Bypass · not yet recruiting
NCT07516535 — DISS vs FANS in Suction-Assisted RIRS for Medium-Sized Renal Stones · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04145492 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ain Shams University
Last refreshed: 30 October 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04145492.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing