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NCT04145011
Coolief Cooled Radiofrequency vs. Conventional Radiofrequency to Manage OA Knee Pain
NA trial testing Cooled Radiofrequency in Osteoarthritis of the Knee in 153 participants. Completed in 10 October 2022.
29 October 2021
Quick facts
| Lead sponsor | Avanos Medical |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 153 |
| Start date | 4 October 2019 |
| Primary completion | 29 October 2021 |
| Estimated completion | 10 October 2022 |
| Sites | 7 locations across United States |
Drugs / interventions tested
- Cooled Radiofrequency
- Standard Radiofrequency
Conditions studied
- Osteoarthritis of the Knee — all drugs for Osteoarthritis of the Knee →
Sponsor
Avanos Medical
Who can join
21 and older, any sex, with Osteoarthritis of the Knee. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study is being performed to assess the relative effectiveness of genicular nerve ablation with the COOLIEF\* Cooled Radiofrequency probe to manage moderate to severe knee pain in patients with osteoarthritis (OA) of the knee when compared to radiofrequency ablation using a Standard Radiofrequency probe.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04145011
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Cooled Radiofrequency
Trials testing the same drug.
- NCT03381248 — Cooled Radiofrequency vs. Hyaluronic Acid to Manage Knee Pain · NA · completed
Other recruiting trials for Osteoarthritis of the Knee
Currently open trials in the same condition.
- NCT07302204 — Efficacy of Aerobic Exercise Versus Therapeutic Exercises on Exercise-induced Hypoalgesia in Knee Osteoarthritis · NA · recruiting
- NCT06549686 — A Phase III Study of CLS2901C in Patients With Osteoarthritis of the Knee · Phase 3 · recruiting
- NCT05985785 — Bone Marrow Aspirate Concentrate (BMAC) vs Corticosteroid Injection · NA · recruiting
- NCT05035810 — A Pragmatic Trial to Determine the Benefit of Behaviorally Enhanced Exercise Incentives and Corticosteroid Injections in · Phase 3 · active not recruiting
- NCT04992624 — Cannabinoid Interactions With Central and Peripheral Pain Mechanisms in Osteoarthritis of the Knee · Phase 2 · recruiting
Other Avanos Medical trials
Trials by the same sponsor.
- NCT03601949 — Lateral Branch Cooled Radiofrequency Denervation vs. Conservative Therapy for Sacroiliac Joint Pain · NA · completed
- NCT03381248 — Cooled Radiofrequency vs. Hyaluronic Acid to Manage Knee Pain · NA · completed
- NCT03368976 — PACMAN Ultrasound Recording Data Collection · terminated
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04145011 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Avanos Medical
- Last refreshed: 8 August 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04145011.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing