Who is sponsoring NCT03601949?

NCT03601949 is sponsored by Avanos Medical.

What drugs are being tested in NCT03601949?

Interventions in NCT03601949: SInergy Cooled Radiofrequency, Medical Management.

What condition does NCT03601949 study?

NCT03601949 studies Sacroiliac Joint Pain.

Is NCT03601949 still recruiting?

NCT03601949 is currently completed. Last updated 22 March 2023.

Last reviewed 2023-03-22 · How we verify

NCT03601949

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Lateral Branch Cooled Radiofrequency Denervation vs. Conservative Therapy for Sacroiliac Joint Pain

Completed NA Last updated 22 March 2023

What this trial tests

NA trial testing SInergy Cooled Radiofrequency in Sacroiliac Joint Pain in 210 participants. Completed in 23 June 2022.

Timeline

29 June 2018

Primary endpoint
9 August 2021

23 June 2022

Quick facts

Lead sponsor	Avanos Medical
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	210
Start date	29 June 2018
Primary completion	9 August 2021
Estimated completion	23 June 2022
Sites	15 locations across United States

Drugs / interventions tested

SInergy Cooled Radiofrequency
Medical Management — full drug profile →

Conditions studied

Sacroiliac Joint Pain — all drugs for Sacroiliac Joint Pain →

Sponsor

Avanos Medical

Who can join

Adults 21 to 110, any sex, with Sacroiliac Joint Pain. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a prospective, randomized, controlled, multi-center clinical study. Approximately 208 subjects will be enrolled at approximately 12-15 active duty military, veterans' care, and civilian sites. Eligible subjects will be randomized in 1:1 ratio to receive either Sacroiliac denervation using CRF (treatment group) or standard medical management ("SMM," control group).

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Cooled radiofrequency ablation versus standard medical management for chronic sacroiliac joint pain: a multicenter, randomized comparative effectiveness study.
Cohen SP, Kapural L, Kohan L, Li S, et al · · 2024 · cited 13× · PMID 37407279 · DOI 10.1136/rapm-2023-104568
Cooled radiofrequency ablation provides extended clinical utility in the management of chronic sacroiliac joint pain: 12-month follow-up results from the observational phase of a randomized, multicenter, comparative-effectiveness crossover study.
Cohen SP, Kapural L, Kohan L, Li S, et al · · 2026 · cited 3× · PMID 40089310 · DOI 10.1136/rapm-2024-106315

Verify or expand the search:

Other Avanos Medical trials

Trials by the same sponsor.

NCT04145011 — Coolief Cooled Radiofrequency vs. Conventional Radiofrequency to Manage OA Knee Pain · NA · completed
NCT03381248 — Cooled Radiofrequency vs. Hyaluronic Acid to Manage Knee Pain · NA · completed
NCT03368976 — PACMAN Ultrasound Recording Data Collection · terminated

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03601949 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Avanos Medical
Last refreshed: 22 March 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03601949.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing