NCT04144972 is a NA clinical trial of Medtronic Summit RC+S or Percept RC in Spinal Cord Injuries, sponsored by University of California, San Francisco.

Who is sponsoring NCT04144972?

NCT04144972 is sponsored by University of California, San Francisco.

What drugs are being tested in NCT04144972?

Interventions in NCT04144972: Medtronic Summit RC+S or Percept RC.

What condition does NCT04144972 study?

NCT04144972 studies Spinal Cord Injuries, Nerve Injury, Pain, Postoperative, Post Herpetic Neuralgia, Complex Regional Pain Syndromes, Post-Stroke Pain, Post Radiation Brain Injury, Post Radiation Plexopathy, Nerve Root Avulsion.

Is NCT04144972 still recruiting?

NCT04144972 is currently recruiting now. Last updated 8 July 2025.

Last reviewed 2025-07-08 · How we verify

NCT04144972

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain

Recruiting now NA Last updated 8 July 2025

What this trial tests

NA trial testing Medtronic Summit RC+S or Percept RC in Spinal Cord Injuries in 12 participants. Currently enrolling.

Timeline

24 October 2019

Primary endpoint
24 October 2029

24 October 2030

Quick facts

Lead sponsor	University of California, San Francisco
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	treatment
Enrollment	12
Start date	24 October 2019
Primary completion	24 October 2029
Estimated completion	24 October 2030
Sites	1 location across United States

Drugs / interventions tested

Medtronic Summit RC+S or Percept RC

Conditions studied

Spinal Cord Injuries — all drugs for Spinal Cord Injuries →
Nerve Injury — all drugs for Nerve Injury →
Pain, Postoperative — all drugs for Pain, Postoperative →
Post Herpetic Neuralgia — all drugs for Post Herpetic Neuralgia →

Sponsor

University of California, San Francisco

Who can join

Adults 22 to 80, any sex, with Spinal Cord Injuries or Nerve Injury. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Chronic pain affects 1 in 4 US adults, and many cases are resistant to almost any treatment. Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but traditional approaches target only brain regions involved in one aspect of the pain experience and provide continuous 24/7 brain stimulation which may lose effect over time. By developing new technology that targets multiple, complimentary brain regions in an adaptive fashion, the investigators will test a new therapy for chronic pain that has potential for better, more enduring analgesia.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Analysis-rcs-data: Open-Source Toolbox for the Ingestion, Time-Alignment, and Visualization of Sense and Stimulation Data From the Medtronic Summit RC+S System.
Sellers KK, Gilron R, Anso J, Louie KH, et al · · 2021 · cited 41× · PMID 34322004 · DOI 10.3389/fnhum.2021.714256
Deep Brain Stimulation for the Management of Refractory Neurological Disorders: A Comprehensive Review.
Rissardo JP, Vora NM, Tariq I, Mujtaba A, et al · · 2023 · cited 17× · PMID 38004040 · DOI 10.3390/medicina59111991
Practical Closed-Loop Strategies for Deep Brain Stimulation: Lessons From Chronic Pain.
Prosky J, Cagle J, Sellers KK, Gilron R, et al · · 2021 · cited 17× · PMID 34975374 · DOI 10.3389/fnins.2021.762097
Personalized, closed-loop deep brain stimulation for chronic pain
Shirvalkar P, Leriche R, Saal J, Cagle J, et al · · 2025 · cited 2× · DOI 10.1101/2025.08.11.25333010

Verify or expand the search:

Other recruiting trials for Spinal Cord Injuries

Currently open trials in the same condition.

NCT07109804 — Cuneiform Nucleus (CnF) Deep Brain Stimulation for Gait Facilitation Following Spinal Cord Injury · NA · recruiting
NCT07472985 — Protocol for Rapid Onset of Mobilization in Patients With Traumatic Spinal Cord Injury II (PROMPT-SCI II) Trial · NA · recruiting
NCT07210411 — Acute and Chronic Repercussion of Spinal Cord Stimulation After Spinal Cord Injury · NA · recruiting
NCT07488793 — Remote Ischemic Conditioning for PwSCI · NA · recruiting
NCT07536386 — Self-balancing Personal Exoskeleton for SCI (WIP) · NA · recruiting

Other University of California, San Francisco trials

Trials by the same sponsor.

NCT05284773 — Screening for Acute Malnutrition · NA · withdrawn
NCT04634851 — Video Home Visits for Dietary Counselling · NA · not yet recruiting
NCT06065670 — Assessing Changes in Multi-parametric MRI in Patients With Acute Demyelinating Lesions Taking Clemastine Fumarate as a M · Phase 1, PHASE2 · not yet recruiting
NCT07534098 — Intervention for Hearing Health Among Native Americans · NA · not yet recruiting
NCT06960421 — Exercise-based Frailty Intervention in Lung Transplantation (XFIT) · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04144972 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of California, San Francisco
Last refreshed: 8 July 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04144972.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing