NCT04144933 (RUMBLE) is a Phase 3 clinical trial of Acetaminophen, Gabapentin in Anesthesia, sponsored by University of Saskatchewan.

Who is sponsoring NCT04144933?

NCT04144933 is sponsored by University of Saskatchewan.

What drugs are being tested in NCT04144933?

Interventions in NCT04144933: Acetaminophen, Gabapentin, Acetaminophen, Gabapentin, Lidocaine 1% Injectable Solution, Dexmedetomidine, Ketamine, Dexamethasone, Ondansetron, Sevoflurane, Lidocaine 2% Injectable Solution, Ketamine, Dexmedetomidine, Magnesium Sulfate, Lidocaine 1% Injectable Solution, Sufentanil, Sevoflurane, Sufentanil.

What condition does NCT04144933 study?

NCT04144933 studies Anesthesia, General Anesthesia, Analgesics, Opioid, Opioid Free Anesthesia, Postoperative Ileus, Colorectal Surgery, Laparoscopic Surgery, Analgesia, Dexmedetomidine, Lidocaine, Ketamine.

Is NCT04144933 still recruiting?

NCT04144933 is currently status unknown. Last updated 20 December 2023.

Last reviewed 2023-12-20 · How we verify

NCT04144933: RUMBLE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery

Status unknown Phase 3 Last updated 20 December 2023

What this trial tests

Phase 3 trial testing Acetaminophen, Gabapentin in Anesthesia in 60 participants. Status unknown.

Timeline

15 May 2021

Primary endpoint
30 July 2024

1 August 2024

Quick facts

Lead sponsor	University of Saskatchewan
Phase	Phase 3
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	prevention
Enrollment	60
Start date	15 May 2021
Primary completion	30 July 2024
Estimated completion	1 August 2024
Sites	1 location across Canada

Drugs / interventions tested

Acetaminophen, Gabapentin — full drug profile →
Acetaminophen, Gabapentin — full drug profile →
Lidocaine 1% Injectable Solution, Dexmedetomidine, Ketamine — full drug profile →
Dexamethasone, Ondansetron
Sevoflurane, Lidocaine 2% Injectable Solution, Ketamine, Dexmedetomidine, Magnesium Sulfate — full drug profile →
Lidocaine 1% Injectable Solution, Sufentanil — full drug profile →
Sevoflurane, Sufentanil — full drug profile →

Conditions studied

Anesthesia — all drugs for Anesthesia →
General Anesthesia — all drugs for General Anesthesia →
Analgesics, Opioid — all drugs for Analgesics, Opioid →
Opioid Free Anesthesia — all drugs for Opioid Free Anesthesia →

Sponsor

University of Saskatchewan

Who can join

18 and older, any sex, with Anesthesia or General Anesthesia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The objective of this study is to determine if an opioid-free general anesthetic (OFA) technique utilizing lidocaine, ketamine, dexmedetomidine and magnesium reduce postoperative opioid consumption and speed return of bowel function in patients undergoing elective, laparoscopic, colorectal surgery compared to traditional opioid-containing general anesthetic techniques. It is hypothesized that this intraoperative OFA regimen will reduce postoperative opioid consumption, and expedite return of bowel function in this population.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other recruiting trials for Anesthesia

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Other University of Saskatchewan trials

Trials by the same sponsor.

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NCT06946316 — Dairy vs Plant-based Beverages for Improving Bone Health During Exercise · NA · recruiting
NCT04276857 — Systemic Therapy With a Loco-regional Treatment in Patients With Locally Advanced Pancreatic Cancer · NA · recruiting
NCT03401294 — Conversion From Unresectable To Resectable Metastatic Colorectal Cancer. · Phase 2 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04144933 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Saskatchewan
Last refreshed: 20 December 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04144933.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing