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Lidocaine 1% Injectable Solution, Sufentanil
This combination drug uses lidocaine as a local anesthetic to block nerve conduction and sufentanil as an opioid analgesic to provide pain relief through mu-opioid receptor activation.
This combination drug uses lidocaine as a local anesthetic to block nerve conduction and sufentanil as an opioid analgesic to provide pain relief through mu-opioid receptor activation. Used for Local anesthesia with systemic analgesia (specific indication in phase 3 trial not publicly detailed).
At a glance
| Generic name | Lidocaine 1% Injectable Solution, Sufentanil |
|---|---|
| Also known as | Opioid-containing pre-intubation medications |
| Sponsor | University of Saskatchewan |
| Drug class | Local anesthetic + opioid analgesic combination |
| Target | Voltage-gated sodium channels (lidocaine); mu-opioid receptor (sufentanil) |
| Modality | Small molecule |
| Therapeutic area | Pain Management / Anesthesia |
| Phase | Phase 3 |
Mechanism of action
Lidocaine works by blocking sodium channels in nerve membranes, preventing the initiation and propagation of action potentials in sensory nerves. Sufentanil is a potent synthetic opioid agonist that binds to mu-opioid receptors in the central and peripheral nervous system to produce analgesia and sedation. Together, they provide both local and systemic pain control.
Approved indications
- Local anesthesia with systemic analgesia (specific indication in phase 3 trial not publicly detailed)
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Nausea
- Dizziness
- Local injection site reactions
Key clinical trials
- Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy (NA)
- Dose Systemic Lidocaine Improve the Quality of Recovery After Colorectal Endoscopic Submucosal Dissection (PHASE4)
- Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery (PHASE3)
- Pharmacokinetics of Sufentanil After Epidural Administration
- Intraperitoneal Lidocaine in Ovarian Cancer Surgery (NA)
- Comparison of Combined Spinal-epidural Analgesia Versus Epidural Analgesia for Pain Management During Labor (NA)
- The Association Between Epidural Labor Analgesia and Pregnancy Outcomes (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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