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NCT04127487
Quantification of NLRP3 (rs4612666) and CARD8 Gene (rs2043211) in Generalized Chronic Periodontitis Subjects
trial in Periodontal Diseases in 70 participants. Status unknown.
1 November 2020
Quick facts
| Lead sponsor | Meenakshi Ammal Dental College and Hospital |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 70 |
| Start date | 1 October 2019 |
| Primary completion | 1 November 2020 |
| Estimated completion | 1 December 2020 |
| Sites | 1 location across India |
Conditions studied
- Periodontal Diseases — all drugs for Periodontal Diseases →
- Coronary Artery Disease — all drugs for Coronary Artery Disease →
Sponsor
Meenakshi Ammal Dental College and Hospital
Who can join
Adults 30 to 65, male only, with Periodontal Diseases or Coronary Artery Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Quantification of NLRP3 (rs4612666) and CARD8 (rs20432111) will be analysed in the subgingival plaque and blood samples of generalized chronic periodontitis with and without coronary heart disease. The demographic and the periodontal parameters were assessed and correlated with the quantification of NLRP3 (rs4612666) and CARD8 (rs2043211) was analysed with RT-PCR
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
NLRP3 inflammasome: a key player in the pathogenesis of life-style disorders.
Ramachandran R, Manan A, Kim J, Choi S. · · 2024 · cited 67× · PMID 38945951 · DOI 10.1038/s12276-024-01261-8 -
Genetic Polymorphisms of NLRP3 (rs4612666) and CARD8 (rs2043211) in Periodontitis and Cardiovascular Diseases.
Mahendra J, Rao AN, Mahendra L, Fageeh HN, et al · · 2021 · cited 7× · PMID 34199122 · DOI 10.3390/biology10070592
Verify or expand the search:
- PubMed search for NCT04127487
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Periodontal Diseases
Currently open trials in the same condition.
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- NCT07384221 — Periodontal Status and Disease Severity in Pemphigus Vulgaris Patients · recruiting
- NCT07530978 — ORAL HYGIENE, PERIODONTAL STATUS AND QUALITY OF LIFE · recruiting
- NCT06848790 — Interdental Hygiene Methods in Young Adults · NA · recruiting
Other Meenakshi Ammal Dental College and Hospital trials
Trials by the same sponsor.
- NCT07504744 — Klotho Gene, Red Complex Bacteria and Periodontal Viruses in Patients With and Without Periodontitis and Acute Coronary · not yet recruiting
- NCT07353606 — Cofilin-2 (rs80358250) and Lactoferrin (rs1126478) Polymorphism and Protein Levels With Non Surgical Periodontal Therapy · NA · active not recruiting
- NCT05828368 — DKK-3 rs11544814 and CFH rs10737680 Polymorphism and Protein Levels With Non Surgical Periodontal Therapy in Periodontit · NA · unknown
- NCT05663476 — NSPT On Vitronectin And Fetuin-A Levels In Patients With Periodontitis And Coronary Artery Disease · NA · unknown
- NCT05618743 — NSPT on Calprotectin and Periostin Levels · NA · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04127487 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Meenakshi Ammal Dental College and Hospital
- Last refreshed: 3 December 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04127487.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing