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NCT05663476
NSPT On Vitronectin And Fetuin-A Levels In Patients With Periodontitis And Coronary Artery Disease
NA trial testing Non Surgical Periodontal Therapy in Chronic Periodontitis in 60 participants. Status unknown.
30 December 2023
Quick facts
| Lead sponsor | Meenakshi Ammal Dental College and Hospital |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 1 May 2023 |
| Primary completion | 30 December 2023 |
| Estimated completion | 1 May 2024 |
| Sites | 1 location across India |
Drugs / interventions tested
- Non Surgical Periodontal Therapy
Conditions studied
- Chronic Periodontitis — all drugs for Chronic Periodontitis →
- Cardiovascular Diseases — all drugs for Cardiovascular Diseases →
- Periodontal Inflammation — all drugs for Periodontal Inflammation →
Sponsor
Meenakshi Ammal Dental College and Hospital
Who can join
Adults 30 to 65, male only, with Chronic Periodontitis or Cardiovascular Diseases. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Periodontitis is a chronic inflammatory disease mainly caused by the oral microbial biofilm. It involves the periodontal supporting tissues mainly features gum inflammation, alveolar bone resorption, periodontal pocket formation, and tooth loosening but also induces various systemic diseases, which seriously affect the physical and mental health of patients. The response to periodontal infection is mediated by various intracellular signalling pathways leading to the production of numerous bio-molecules. Vitronectin is a multifunctional protein with a multiple binding domain that interacts with a variety of plasma and cell proteins. It belongs to the group of adhesive glycoproteins that is involved in various functions including complement activation, blood coagulation, binding to proteoglycans, and modification of the matrix. Among the various cystatins expressed in serum and saliva, Fetuin-A, an another protein is produced majorly by healthy hepatic and adipose tissues. Fetuin-A has been recognized as a multifunctional molecule related to its role in metabolic processes, insulin resistance, regulation of adipogenesis and mineralization throughout the body. The study aims to determine the expression of Vitronectin and Fetuin-A as potential pro-inflammatory and anti-inflammatory biomarkers respectively. These protein molecules can further play a role as putative risk indicators in periodontitis subjects with and without coronary artery disease following non-surgical therapy.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05663476
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Related trials
Other trials of Non Surgical Periodontal Therapy
Trials testing the same drug.
- NCT06050174 — Azadirachta Indica (Neem) Extract as an Adjunct to Non-Surgical Periodontal Management · Phase 2 · completed
- NCT05618743 — NSPT on Calprotectin and Periostin Levels · NA · unknown
- NCT04739475 — Effect of Stress on Periodontal Therapy (NPT) · NA · completed
Other recruiting trials for Chronic Periodontitis
Currently open trials in the same condition.
- NCT06893107 — Study on Treatment Results and Bone Changes After Replanting Severely Affected Teeth - A Before-and-After Study. · NA · recruiting
- NCT05275192 — Utilization of a Videoscope in Periodontal Regeneration · NA · recruiting
- NCT03741374 — Minimally-invasive Non-surgical Therapy of Intrabony Defects · NA · active not recruiting
- NCT03553095 — Comparing Inflammatory Markers in Patients With and Without Depression With Chronic Periodontitis · NA · active not recruiting
Other Meenakshi Ammal Dental College and Hospital trials
Trials by the same sponsor.
- NCT07504744 — Klotho Gene, Red Complex Bacteria and Periodontal Viruses in Patients With and Without Periodontitis and Acute Coronary · not yet recruiting
- NCT07353606 — Cofilin-2 (rs80358250) and Lactoferrin (rs1126478) Polymorphism and Protein Levels With Non Surgical Periodontal Therapy · NA · active not recruiting
- NCT05828368 — DKK-3 rs11544814 and CFH rs10737680 Polymorphism and Protein Levels With Non Surgical Periodontal Therapy in Periodontit · NA · unknown
- NCT05618743 — NSPT on Calprotectin and Periostin Levels · NA · unknown
- NCT04127474 — Expression of Trefoil Factors and Adrenomedullin in Subjects With Chronic Periodontitis and Coronary Heart Disease · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05663476 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Meenakshi Ammal Dental College and Hospital
- Last refreshed: 13 April 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05663476.
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