Who is sponsoring NCT03741374?

NCT03741374 is sponsored by Queen Mary University of London.

What drugs are being tested in NCT03741374?

Interventions in NCT03741374: Minimally-invasive non-surgical therapy (MINST).

What condition does NCT03741374 study?

NCT03741374 studies Chronic Periodontitis.

Is NCT03741374 still recruiting?

NCT03741374 is currently active, enrolled. Last updated 8 June 2025.

Last reviewed 2025-06-08 · How we verify

NCT03741374

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Minimally-invasive Non-surgical Therapy of Intrabony Defects

Active, enrolled NA Last updated 8 June 2025

What this trial tests

NA trial testing Minimally-invasive non-surgical therapy (MINST) in Chronic Periodontitis in 66 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

1 February 2019

Primary endpoint
31 December 2025

31 December 2025

Quick facts

Lead sponsor	Queen Mary University of London
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	66
Start date	1 February 2019
Primary completion	31 December 2025
Estimated completion	31 December 2025
Sites	9 locations across Italy, United Kingdom, Australia, Spain

Drugs / interventions tested

Minimally-invasive non-surgical therapy (MINST)

Conditions studied

Chronic Periodontitis — all drugs for Chronic Periodontitis →

Sponsor

Queen Mary University of London

Who can join

Adults 18 to 70, any sex, with Chronic Periodontitis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This investigation aims to assess the clinical and radiographic outcomes of intrabony defects treated with minimally-invasive non-surgical therapy.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Minimally invasive non-surgical vs. surgical approach for periodontal intrabony defects: a randomised controlled trial.
Nibali L, Koidou V, Salomone S, Hamborg T, et al · · 2019 · cited 22× · PMID 31351492 · DOI 10.1186/s13063-019-3544-8
Minimally invasive non-surgical periodontal therapy of intrabony defects: A prospective multi-centre cohort study.
Mehta J, Montevecchi M, Garcia-Sanchez R, Onabolu O, et al · · 2024 · cited 13× · PMID 38710583 · DOI 10.1111/jcpe.13984

Verify or expand the search:

Other trials of Minimally-invasive non-surgical therapy (MINST)

Trials testing the same drug.

NCT04236648 — Minimally-invasive Non-surgical Treatment in Teeth With Unfavourable Prognosis · NA · unknown

Other recruiting trials for Chronic Periodontitis

Currently open trials in the same condition.

NCT06893107 — Study on Treatment Results and Bone Changes After Replanting Severely Affected Teeth - A Before-and-After Study. · NA · recruiting
NCT05275192 — Utilization of a Videoscope in Periodontal Regeneration · NA · recruiting
NCT03553095 — Comparing Inflammatory Markers in Patients With and Without Depression With Chronic Periodontitis · NA · active not recruiting

Other Queen Mary University of London trials

Trials by the same sponsor.

NCT07246005 — LVT DURATION: Pilot Study of Anticoagulation Duration for Left Ventricular Thrombus · Phase 2 · not yet recruiting
NCT07165678 — CTCA Prior to Invasive Angiography in Post-Bypass Patients (BYPASS CTCA 2) · NA · not yet recruiting
NCT06937372 — Delivery and Implementation of a Randomised Crossover Trial on Thrombosis · NA · not yet recruiting
NCT06600438 — Slow-SPEED UK: A Double-Blind Randomised Feasibility Trial · NA · not yet recruiting
NCT06987045 — Trans and Non-binary Prostate-Specific Antigen Reference Interval Determination Study · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03741374 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Queen Mary University of London
Last refreshed: 8 June 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03741374.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing