NCT04040127 is a Phase 2 clinical trial of Cord blood stem cells in Irreversible Pulpitis, sponsored by University of California, San Francisco.

Who is sponsoring NCT04040127?

NCT04040127 is sponsored by University of California, San Francisco.

What drugs are being tested in NCT04040127?

Interventions in NCT04040127: Cord blood stem cells, Saline solution.

What condition does NCT04040127 study?

NCT04040127 studies Irreversible Pulpitis.

Is NCT04040127 still recruiting?

NCT04040127 is currently withdrawn. Last updated 27 July 2020.

Last reviewed 2020-07-27 · How we verify

NCT04040127

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Residual Dental Pulp Tissue and Cord Blood Stem Cells

Withdrawn Phase 2 Last updated 27 July 2020

What this trial tests

Phase 2 trial testing Cord blood stem cells in Irreversible Pulpitis. Withdrawn.

Timeline

1 September 2019

Primary endpoint
15 January 2020

28 February 2020

Quick facts

Lead sponsor	University of California, San Francisco
Phase	Phase 2
Status	Withdrawn
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Start date	1 September 2019
Primary completion	15 January 2020
Estimated completion	28 February 2020

Drugs / interventions tested

Cord blood stem cells — full drug profile →
Saline solution

Conditions studied

Irreversible Pulpitis — all drugs for Irreversible Pulpitis →

Sponsor

University of California, San Francisco

Who can join

18 and older, any sex, with Irreversible Pulpitis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The experiments outlined in this proposal are designed to test the hypothesis that the in vivo injection of cord blood stem cells (InvitRx®) into the root canal system will facilitate teeth initially diagnosed with irreversible pulpitis, to form normal healthy pulpal tissue.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Wharton's jelly mesenchymal stem cells: Future regenerative medicine for clinical applications in mitigation of radiation injury.
Sharma P, Maurya DK. · · 2024 · cited 12× · PMID 39086560 · DOI 10.4252/wjsc.v16.i7.742

Verify or expand the search:

Other trials of Cord blood stem cells

Trials testing the same drug.

NCT03885947 — VPA Expanded UCB Transplantation for Treatment of Patients With Hematological Malignancies · Phase 1 · completed

Other recruiting trials for Irreversible Pulpitis

Currently open trials in the same condition.

NCT07233564 — Comparison of Pain Between Supraperiosteal Injection of Dexamethasone Versus Placebo on Postoperative Pain in Teeth With · NA · active not recruiting
NCT06843525 — Bite Force Measurements · recruiting
NCT07163975 — Complete Pulpotomy and Root Canal Treatment Patients With Irreversible Pulpitis With Type 2 Diabetes Mellitus · NA · recruiting
NCT07073573 — Evaluation of Pulpal Biomarkers in Vital Pulp Therapy · NA · active not recruiting
NCT06730360 — Clinical and Radiographic Assessment of Photobiomodulated MTA Pulpotomy in Immature First Permanent Molars with Irrevers · NA · recruiting

Other University of California, San Francisco trials

Trials by the same sponsor.

NCT05284773 — Screening for Acute Malnutrition · NA · withdrawn
NCT04634851 — Video Home Visits for Dietary Counselling · NA · not yet recruiting
NCT06065670 — Assessing Changes in Multi-parametric MRI in Patients With Acute Demyelinating Lesions Taking Clemastine Fumarate as a M · Phase 1, PHASE2 · not yet recruiting
NCT07534098 — Intervention for Hearing Health Among Native Americans · NA · not yet recruiting
NCT06960421 — Exercise-based Frailty Intervention in Lung Transplantation (XFIT) · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04040127 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of California, San Francisco
Last refreshed: 27 July 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04040127.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing