Last reviewed · How we verify
NCT03900221: RESPONSE
French Registry for Monitoring Pregnancies for Multiple Sclerosis
trial testing No intervention in Sclerosis, Multiple in 1,500 participants. Currently enrolling.
12 August 2036
Quick facts
| Lead sponsor | Hospices Civils de Lyon |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 1,500 |
| Start date | 12 August 2019 |
| Primary completion | 12 August 2036 |
| Estimated completion | 12 August 2036 |
| Sites | 48 locations across Martinique, France |
Drugs / interventions tested
- No intervention
Conditions studied
- Sclerosis, Multiple — all drugs for Sclerosis, Multiple →
- Neuromyelitis Optica Spectrum Disorder — all drugs for Neuromyelitis Optica Spectrum Disorder →
- Myelin Oligodendrocyte Glycoprotein (MOG)-Antibody Related Disorders — all drugs for Myelin Oligodendrocyte Glycoprotein (MOG)-Antibody Related Disorders →
- Pregnancy Abnormal — all drugs for Pregnancy Abnormal →
Sponsor
Hospices Civils de Lyon — full company profile →
Who can join
Eligibility, any sex, with Sclerosis, Multiple or Neuromyelitis Optica Spectrum Disorder. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The influence of pregnancy on the course of multiple sclerosis (MS) has long been a controversial topic. After the publication of the first large prospective study of pregnancy and MS in 1998, counselling of women with MS has radically changed and many patients have been able to fulfill their desire of motherhood. However, there are still some challenges for the neurologist, who has to face old unanswered questions or new issues, regarding the use of disease modifying drugs (DMDs) in this period of life, effects on the short and long term outcome of the mother (in terms of relapses and disability) and the child, role of breast-feeding and locoregional analgesia. To set up a national prospective pregnancy registry for patients with MS, nested within the Observatoire Français de la Sclérose en Plaque (OFSEP) cohort, owing to a better knowledge of interactions between MS and pregnancy-related issues (pregnancy itself, locoregional analgesia, breastfeeding, impact of using or stopping DMDs on women/children…)
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT03900221
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Sclerosis, Multiple
Currently open trials in the same condition.
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- NCT06428201 — The Efficacy of Tele Rehabilitation- Based Task-Specific Training for Cognitive Function Improvement · NA · active not recruiting
- NCT05857280 — EXOPULSE Mollii Suit, Motor Function & Multiple Sclerosis (EXOSEP 2) · NA · recruiting
- NCT03600779 — Application of ihMT MRI in Multiple Sclerosis · NA · recruiting
Other Hospices Civils de Lyon trials
Trials by the same sponsor.
- NCT07569536 — Efficacy of the Alpha 2 Agonist Dexmedetomidine for Sympathetic Deactivation in REfractory Septic Shock · Phase 3 · not yet recruiting
- NCT07529314 — Evaluating Interventional Radiology for Cancer Pain Management · NA · not yet recruiting
- NCT07273929 — Comparative Study of the Effectiveness of Three Access Routes for Implanting an Electronic Intracardiac Device · Phase 3 · not yet recruiting
- NCT07474532 — Attitudes and Beliefs Related to Benzodiazepine Deprescribing · not yet recruiting
- NCT07313007 — Assessment of Gut Microbiota-Derived Amino Acid Metabolite Production in Patients With MASLD · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03900221 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospices Civils de Lyon
- Last refreshed: 5 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03900221.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing