NCT03860129 is a NA clinical trial of Isoflurane in Intensive Care Unit Syndrome, sponsored by Ruhr University of Bochum.

Who is sponsoring NCT03860129?

NCT03860129 is sponsored by Ruhr University of Bochum.

What drugs are being tested in NCT03860129?

Interventions in NCT03860129: Isoflurane, Sevoflurane, Desflurane.

What condition does NCT03860129 study?

NCT03860129 studies Intensive Care Unit Syndrome.

Is NCT03860129 still recruiting?

NCT03860129 is currently completed. Last updated 1 March 2019.

Last reviewed 2019-03-01 · How we verify

NCT03860129

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Different Volatile Anaesthetics and the Depth of Long Term ICU Sedation

Completed NA Last updated 1 March 2019

What this trial tests

NA trial testing Isoflurane in Intensive Care Unit Syndrome in 30 participants. Completed in 31 May 2017.

Timeline

10 December 2014

Primary endpoint
5 May 2017

31 May 2017

Quick facts

Lead sponsor	Ruhr University of Bochum
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	health services research
Enrollment	30
Start date	10 December 2014
Primary completion	5 May 2017
Estimated completion	31 May 2017

Drugs / interventions tested

Isoflurane (ISOFLURANE) — full drug profile →
Sevoflurane — full drug profile →
Desflurane (DESFLURANE) — full drug profile →

Conditions studied

Intensive Care Unit Syndrome — all drugs for Intensive Care Unit Syndrome →

Sponsor

Ruhr University of Bochum

Who can join

18 and older, any sex, with Intensive Care Unit Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The MIRUS system (TIM, Andernach, Germany) as well as the AnaConDa uses a reflector to conserve volatile anaesthetics (VA). Both systems can be paired with ICU ventilators, but MIRUS features an automated control of end-tidal VA concentrations (etVA). We compare depth of 0.5 MAC inhalational long-term sedation with Isoflurane (ISO), Sevoflurane (SEVO) or Desflurane (DES).

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Use of MIRUS™ for MAC-driven application of isoflurane, sevoflurane, and desflurane in postoperative ICU patients: a randomized controlled trial.
Bellgardt M, Georgevici AI, Klutzny M, Drees D, et al · · 2019 · cited 15× · PMID 31620921 · DOI 10.1186/s13613-019-0594-8
Negative drift of sedation depth in critically ill patients receiving constant minimum alveolar concentration of isoflurane, sevoflurane, or desflurane: a randomized controlled trial.
Georgevici AI, Kyprianou T, Herzog-Niescery J, Procopiuc L, et al · · 2021 · cited 5× · PMID 33849618 · DOI 10.1186/s13054-021-03556-y
Negative Drift of Sedation Depth In Critically Ill Patients Receiving Constant Minimum Alveolar Concentration of Isoflurane, Sevoflurane, or Desflurane: A Randomized Controlled Trial
Georgevici AI, Kyprianou T, Herzog-Niescery J, Procopiuc L, et al · · 2021 · DOI 10.21203/rs.3.rs-140001/v1

Verify or expand the search:

Other trials of Isoflurane

Trials testing the same drug.

NCT07460050 — Comparison of Two Sedative Agents in Terms of Controlled Hypotension · NA · not yet recruiting
NCT07152912 — Impact of Isoflurane and Sevoflurane on Oxidative Stress in Patients Undergoing Laparoscopic Cholecystectomy · NA · recruiting
NCT06624592 — Sevoflurane/Dexmedetomidine vs. Isoflurane for Pediatric Emergence Delirium · Phase 3 · recruiting
NCT05830864 — Multicenter Retrospective Study of Isoflurane in Refractory and Super-Refractory Status Epilepticus · completed
NCT06311604 — Evaluation of the Safety of Inhaled Sedation With Isoflurane in Head Trauma Patients · NA · recruiting

Other recruiting trials for Intensive Care Unit Syndrome

Currently open trials in the same condition.

NCT06427265 — Machine Learning-based Longitudinal Study of Post-ICU Syndrome Development Trajectory in Critically Ill Patients and Con · recruiting
NCT03753412 — Recovery From ICUAW Following Severe Respiratory and Cardiac Failure · recruiting

Other Ruhr University of Bochum trials

Trials by the same sponsor.

NCT07432945 — In Vivo Exposure vs. Videochat-Based Vicarious Exposure · NA · recruiting
NCT06255821 — The Effect of Time on Generalization of Exposure-based Benefit · NA · completed
NCT05824884 — Self-efficacy Enhancement in a Virtual Reality Training for Fear of Heights · NA · recruiting
NCT05798078 — The Relationship Between Social Anxiety and Anxious Thinking Styles · NA · completed
NCT05780203 — CBM in the Context of Exposure for Acrophobia · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03860129 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ruhr University of Bochum
Last refreshed: 1 March 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03860129.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing