NCT03851159 is a NA clinical trial of Nyaditum resae® in Tuberculosis, sponsored by University of Stellenbosch.

Who is sponsoring NCT03851159?

NCT03851159 is sponsored by University of Stellenbosch.

What drugs are being tested in NCT03851159?

Interventions in NCT03851159: Nyaditum resae®, Mannitol.

What condition does NCT03851159 study?

NCT03851159 studies Tuberculosis.

Is NCT03851159 still recruiting?

NCT03851159 is currently active, enrolled. Last updated 16 May 2025.

Last reviewed 2025-05-16 · How we verify

NCT03851159

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Nyaditum Resae® as a Co-adjuvant During Treatment for Active Pulmonary Tuberculosis and Its Impact on the Gut Microbiota

Active, enrolled NA Last updated 16 May 2025

What this trial tests

NA trial testing Nyaditum resae® in Tuberculosis in 48 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

10 May 2019

Primary endpoint
31 December 2025

31 December 2025

Quick facts

Lead sponsor	University of Stellenbosch
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	other
Enrollment	48
Start date	10 May 2019
Primary completion	31 December 2025
Estimated completion	31 December 2025
Sites	2 locations across South Africa

Drugs / interventions tested

Nyaditum resae®
Mannitol (Mannitol) — full drug profile →

Conditions studied

Tuberculosis — all drugs for Tuberculosis →

Sponsor

University of Stellenbosch

Who can join

Adults 18 to 65, any sex, with Tuberculosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This will be the first study to evaluate the use of Nyaditum resae® as a potential agent for reducing antibiotic-associated gut dysbiosis in patients with drug-susceptible TB, and potentially improving clinical and microbiological markers of outcome

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Microbiome-immune interactions in tuberculosis.
Mori G, Morrison M, Blumenthal A. · · 2021 · cited 45× · PMID 33857251 · DOI 10.1371/journal.ppat.1009377

Verify or expand the search:

Other recruiting trials for Tuberculosis

Currently open trials in the same condition.

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Other University of Stellenbosch trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03851159 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Stellenbosch
Last refreshed: 16 May 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03851159.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing