NCT03843281 (ParaMoED) is a Phase 4 clinical trial of Paracetamol in Analgesia, sponsored by Bruno Minotti.

Who is sponsoring NCT03843281?

NCT03843281 is sponsored by Bruno Minotti.

What drugs are being tested in NCT03843281?

Interventions in NCT03843281: Paracetamol, Placebo, Morphine.

Is NCT03843281 still recruiting?

NCT03843281 is currently completed. Last updated 19 October 2020.

Last reviewed 2020-10-19 · How we verify

NCT03843281: ParaMoED

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Efficacy of Paracetamol in Addition to Morphine to Improve Analgesia in the Emergency Department

Completed Phase 4 Last updated 19 October 2020

What this trial tests

Phase 4 trial testing Paracetamol in Analgesia in 222 participants. Completed in 15 October 2020.

Timeline

2 May 2019

Primary endpoint
15 October 2020

15 October 2020

Quick facts

Lead sponsor	Bruno Minotti
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	222
Start date	2 May 2019
Primary completion	15 October 2020
Estimated completion	15 October 2020
Sites	1 location across Switzerland

Drugs / interventions tested

Paracetamol (Paracetamol) — full drug profile →
Placebo
Morphine

Conditions studied

Analgesia — all drugs for Analgesia →

Sponsor

Bruno Minotti

Who can join

18 and older, any sex, with Analgesia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to test the additional effect of paracetamol in combination with morphine for analgesia, respectively to test/confirm an opioid sparing effect due to the additional use of Paracetamol, as well as the reduction of adverse drug reactions of morphine.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Intravenous acetaminophen does not reduce morphine use for pain relief in emergency department patients: A multicenter, randomized, double-blind, placebo-controlled trial.
Minotti B, Mansella G, Sieber R, Ott A, et al · · 2022 · cited 8× · PMID 35491963 · DOI 10.1111/acem.14517

Verify or expand the search:

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Other recruiting trials for Analgesia

Currently open trials in the same condition.

NCT07249827 — A Randomized Comparison Between 0.67 mcg/kg, 1 mcg/kg, and 1.33 mcg/kg of Perineural Dexmedetomidine for Ultrasound-Guid · Phase 2 · recruiting
NCT07250230 — Effect of Perioperative High-dose Transdermal Nicotine Patch on Pain Sensitivity Among Male Abstinent Tobacco Smokers Un · NA · recruiting
NCT07337629 — Single Dose Preemptive Paracetamol or Ibuprofen Before Septrorhinoplasty on Intra- and Postoperative Opioid Consumption. · recruiting
NCT07310953 — Clinical Utility of the Numerical Verbal Scale (NVS) and the Pain and Functional Activity Scale (PFAS) in the Management · NA · recruiting
NCT06869967 — Evaluation of Postoperative Pain Control in Ear Surgery · NA · recruiting

Other Bruno Minotti trials

Trials by the same sponsor.

NCT06408519 — Open-Label Placebo for Non-Specific Pain in the ED · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03843281 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Bruno Minotti
Last refreshed: 19 October 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03843281.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing