NCT03823794

Trends in the Epidemiology and Treatment of Atopic Dermatitis in the United Kingdom (UK)

Completed Results posted Last updated 6 June 2025

What this trial tests

trial testing No intervention in Atopic Dermatitis Eczema in 148,166 participants. Completed in 4 November 2020.

Timeline

1 February 2019

Primary endpoint
4 November 2020

4 November 2020

Quick facts

Lead sponsor	Momentum Data
Status	Completed
Study type	OBSERVATIONAL
Enrollment	148,166
Start date	1 February 2019
Primary completion	4 November 2020
Estimated completion	4 November 2020
Sites	1 location across United Kingdom

Drugs / interventions tested

• No intervention

Conditions studied

• Atopic Dermatitis Eczema — all drugs for Atopic Dermatitis Eczema →
• Atopic Dermatitis — all drugs for Atopic Dermatitis →
• Eczema — all drugs for Eczema →

Sponsor

Momentum Data

Who can join

0 and older, any sex, with Atopic Dermatitis Eczema or Atopic Dermatitis. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Prescription Rates for Atopic Dermatitis Related Treatments: Emollients and Soap Substitutes Primary · Jan - Dec 2018 inclusive

Proportion of the arm/group receiving at least one prescription for emollients and soap substitutes.

Group	Value	95% CI
Active Atopic Dermatitis	76095

Prescription Rates for Atopic Dermatitis Related Treatments: Mild Topical Corticosteroids (TCS) Primary · Jan - Dec 2018 inclusive

Proportion of the arm/group receiving at least one prescription for mild topical corticosteroids (atopic dermatitis related treatment)

Group	Value	95% CI
Active Atopic Dermatitis	40478

Prescription Rates for Atopic Dermatitis Related Treatments: Moderate Topical Corticosteroids (TCS) Primary · Jan - Dec 2018 inclusive

Proportion of the arm/group receiving at least one prescription for moderate topical corticosteroids (an atopic dermatitis related treatment)

Group	Value	95% CI
Active Atopic Dermatitis	19575

Prescription Rates for Atopic Dermatitis Related Treatments: Potent Topical Corticosteroids (TCS) Primary · Jan - Dec 2018 inclusive

Proportion of the arm/group receiving at least one prescription for potent topical corticosteroids (an atopic dermatitis related treatment)

Group	Value	95% CI
Active Atopic Dermatitis	34997

Prescription Rates for Atopic Dermatitis Related Treatments: Very Potent Topical Corticosteroids (TCS) Primary · Jan - Dec 2018 inclusive

Proportion of the arm/group receiving at least one prescription for very potent topical corticosteroid (an atopic dermatitis related treatment)

Group	Value	95% CI
Active Atopic Dermatitis	6478

Prescription Rates for Atopic Dermatitis Related Treatments: Topical Calcineurin Inhibitors (TCI) Primary · Jan - Dec 2018 inclusive

Proportion of the arm/group receiving at least one prescription for a topical Calcineurin Inhibitor (an atopic dermatitis related treatment)

Group	Value	95% CI
Active Atopic Dermatitis	2683

Prescription Rates for Atopic Dermatitis Related Treatments: Topical Antimicrobials Primary · Jan - Dec 2018 inclusive

Proportion of the arm/group receiving at least one prescription for topical antimicrobials.

Group	Value	95% CI
Active Atopic Dermatitis	19378

Prescription Rates for Atopic Dermatitis Related Treatments: Antihistamin Primary · Jan - Dec 2018 inclusive

Proportion of the arm/group receiving at least one prescription for antihistamin.

Group	Value	95% CI
Active Atopic Dermatitis	29041

Prescription Rates for Atopic Dermatitis Related Treatments: Systemic Immuno-modulatory Therapy Primary · Jan - Dec 2018 inclusive

Proportion of the arm/group receiving at least one prescription for Systemic immuno-modulatory therapy

Group	Value	95% CI
Active Atopic Dermatitis	2785

Prescription Rates for Atopic Dermatitis Related Treatments: Oral Corticosteroids Primary · Jan - Dec 2018 inclusive

Proportion of the arm/group receiving at least one prescription for oral corticosteroids

Group	Value	95% CI
Active Atopic Dermatitis	12087

Specialist Referrals Primary · Jan - Dec 2018 inclusive

Specialist dermatology referral rate in 2018

Group	Value	95% CI
Active Atopic Dermatitis	5.0	4.9 – 5.1

Primary Care Referrals Primary · Jan - Dec 2018 inclusive

Annual rate of primary care consultations in 2018

Group	Value	95% CI
Active Atopic Dermatitis	112.0	111.5 – 112.6

Sponsor's own description

Atopic dermatitis (AD), commonly called eczema, is one of the most frequently occurring skin conditions. It is estimated to affect around one fifth of children in developed countries and is also becoming increasingly common in less developed countries. Exact estimates of how common eczema is, vary considerably and there has not been an in-depth analysis of the number of people with eczema in the UK. It is also unclear which groups of people are most affected and which treatment options are being used.

Most people with eczema are managed by their general practitioner (GP) with only a few people requiring specialist care. GP records therefore provide an excellent opportunity to explore how common eczema is and which treatments are being used currently.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

1. The epidemiology of eczema in children and adults in England: A population-based study using primary care data.
   de Lusignan S, Alexander H, Broderick C, Dennis J, et al · · 2021 · cited 52× · PMID 33179341 · DOI 10.1111/cea.13784
2. Patterns and trends in eczema management in UK primary care (2009-2018): A population-based cohort study.
   de Lusignan S, Alexander H, Broderick C, Dennis J, et al · · 2021 · cited 21× · PMID 33176023 · DOI 10.1111/cea.13783
3. Epidemiology and management of atopic dermatitis in England: an observational cohort study protocol.
   de Lusignan S, de Lusignan S, Alexander H, Broderick C, et al · · 2020 · cited 6× · PMID 32938595 · DOI 10.1136/bmjopen-2020-037518