NCT05727306

Healthcare Disparities in Alopecia Areata

Completed Results posted Last updated 18 June 2025

What this trial tests

trial testing No intervention in Alopecia Areata in 4,052,231 participants. Completed in 6 August 2024.

Timeline

1 October 2022

Primary endpoint
24 July 2024

6 August 2024

Quick facts

Lead sponsor	Momentum Data
Status	Completed
Study type	OBSERVATIONAL
Enrollment	4,052,231
Start date	1 October 2022
Primary completion	24 July 2024
Estimated completion	6 August 2024
Sites	1 location across United Kingdom

Drugs / interventions tested

• No intervention

Conditions studied

• Alopecia Areata — all drugs for Alopecia Areata →

Sponsor

Momentum Data

Who can join

Adults 12 to 95, any sex, with Alopecia Areata. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Likelihood of Depressive Episodes Primary · Data was collected retrospectively, assessed prior to and up to two years following initial Alopecia Areata diagnosis for each participant

Estimated using logistic regression and reported using adjusted odds ratios

Group	Value	95% CI
People With Alopecia Areata	1217
People Without Alopecia Areata (Reference Group)	3576

Likelihood of Recurrent Major Depressive Disorder Primary · Data was collected retrospectively, assessed prior to and up to two years following initial Alopecia Areata diagnosis for each participant

Estimated using logistic regression and reported using adjusted odds ratios

Group	Value	95% CI
People With Alopecia Areata	835
People Without Alopecia Areata (Reference Gropup)	2264

Likelihood of Anxiety Disorder Primary · Data was collected retrospectively, assessed prior to and up to two years following initial Alopecia Areata diagnosis for each participant

Estimated using logistic regression and reported using adjusted odds ratios

Group	Value	95% CI
People With Alopecia Areata	1113
People Without Alopecia Areata (Reference Group)	3188

Relative Incidence of Primary Care Attendances Secondary · Data was collected retrospectively, assessed up to two years following initial Alopecia Areata diagnosis for each participant

Estimated using negative binomial regression and reported as adjusted incidence rate ratio

Group	Value	95% CI
People With Alopecia Areata	39034
People Without Alopecia Areata (Reference Group)	109052

Relative Incidence of Dermatology Referrals Secondary · Data was collected retrospectively, assessed up to two years following initial Alopecia Areata diagnosis for each participant

Estimated using Cox proportional hazard regression and reported as Adjusted hazard ratio

Group	Value	95% CI
People With Alopecia Areata	1352
People Without Alopecia Areata (Reference Group)	743

Relative Incidence Psychological Therapy Secondary · Data was collected retrospectively, assessed up to two years following initial Alopecia Areata diagnosis for each participant

Estimated using Cox proportional hazard regression and reported as adjusted hazard ratio

Group	Value	95% CI
People With Alopecia Areata	248
People Without Alopecia Areata (Reference Group)	672

Relative Incidence of Unemployment Secondary · Data was collected retrospectively, assessed up to two years following initial Alopecia Areata diagnosis for each participant

Unemployment identified by issue of IB113 or ESA113 forms for unemployment. Relative incidence estimated using Cox proportional hazard regression and reported as Adjusted hazard ratio

Group	Value	95% CI
People With Alopecia Areata	89
People Without Alopecia Areata (Reference Group)	209

Relative Incidence of Time Off Work Secondary · Data was collected retrospectively, assessed up to two years following initial Alopecia Areata diagnosis for each participant

Time off work identified by recorded issue of Med 3 certificate in primary care. Relative incidence estimated using Cox proportional hazard regression and reported as Adjusted hazard ratio

Group	Value	95% CI
People With Alopecia Areata	884
People Without Alopecia Areata (Reference Group)	2268

Sponsor's own description

Alopecia areata (AA) is a common immune-mediated non-scarring alopecia often associated with substantial morbidity. There are however, limited population-based data on potential disparities in the burden of AA, including across people of different ethnicities and deprivation.

We aimed to provide the first large-scale, population-based estimate of lifetime risk of AA overall and by important sociodemographic subgroups. As AA is associated with an increased burden of mental health conditions and work-related outcomes (unemployment, time off work), a detailed understanding of the burden of disease in different sociodemographic groups is vital to plan resource provision.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.