NCT03822546 is a NA clinical trial of Conventional cigarette in Healthy Volunteers, sponsored by Fontem Ventures BV.

Who is sponsoring NCT03822546?

NCT03822546 is sponsored by Fontem Ventures BV.

What drugs are being tested in NCT03822546?

Interventions in NCT03822546: Conventional cigarette, myblu 25 mg freebase, myblu 16 mg nicotine salt, myblu 25 mg nicotine salt, myblu 40 mg nicotine salt, blu PRO 48 mg nicotine salt.

What condition does NCT03822546 study?

NCT03822546 studies Healthy Volunteers.

Is NCT03822546 still recruiting?

NCT03822546 is currently completed. Last updated 30 January 2019.

Last reviewed 2019-01-30 · How we verify

NCT03822546

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

A Study to Evaluate the Pharmacokinetic Profiles of Cigarettes and E-Cigarettes With Nicotine Salt Formulations

Completed NA Last updated 30 January 2019

What this trial tests

NA trial testing Conventional cigarette in Healthy Volunteers in 15 participants. Completed in 30 April 2018.

Timeline

1 April 2018

Primary endpoint
30 April 2018

30 April 2018

Quick facts

Lead sponsor	Fontem Ventures BV
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	other
Enrollment	15
Start date	1 April 2018
Primary completion	30 April 2018
Estimated completion	30 April 2018
Sites	1 location across United States

Drugs / interventions tested

Conventional cigarette
myblu 25 mg freebase
myblu 16 mg nicotine salt
myblu 25 mg nicotine salt
myblu 40 mg nicotine salt
blu PRO 48 mg nicotine salt

Conditions studied

Healthy Volunteers — all drugs for Healthy Volunteers →

Sponsor

Fontem Ventures BV

Who can join

Adults 25 to 65, any sex, with Healthy Volunteers. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study evaluated the pharmacokinetic profiles and subjective effects of nicotine from two e-cigarette device platforms with varying concentrations of nicotine lactate (nicotine salt) e-liquid relative to conventional cigarettes. It was designed as a randomized, open-label, cross-over clinical study conducted in 15 healthy US adult smokers.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

A randomised, open-label, cross-over clinical study to evaluate the pharmacokinetic profiles of cigarettes and e-cigarettes with nicotine salt formulations in US adult smokers.
O'Connell G, Pritchard JD, Prue C, Thompson J, et al · · 2019 · cited 77× · PMID 30712148 · DOI 10.1007/s11739-019-02025-3

Verify or expand the search:

Other trials of Conventional cigarette

Trials testing the same drug.

NCT03452124 — The Effects of I Quit Ordinary Smoking on the Arterial Wall and Endothelial Glycocalyx Properties of Smokers · NA · unknown

Other recruiting trials for Healthy Volunteers

Currently open trials in the same condition.

NCT07504003 — Influence of Training Session Duration on Improvements in Physiological Resilience to Exercise · NA · recruiting
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NCT07495813 — A Study to See How RO7763505 Works and How Safe it is When Given to Healthy People and People With Stable Heart Disease · Phase 1 · recruiting
NCT07499050 — A Study of Multiple Doses of Orally Administered RO7795081 in Otherwise Healthy Chinese Adult Participants With Obesity · Phase 1 · recruiting
NCT07342114 — A Dose-Escalation Study of RO7875913 in Healthy Participants · Phase 1 · recruiting

Other Fontem Ventures BV trials

Trials by the same sponsor.

NCT04019626 — A Study to Assess Tobacco-related Biomarkers of Exposure in Smokers Using myBlu E-cigarettes · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03822546 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Fontem Ventures BV
Last refreshed: 30 January 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03822546.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing