Who is sponsoring NCT03791515?

NCT03791515 is sponsored by Danish Headache Center.

What drugs are being tested in NCT03791515?

Interventions in NCT03791515: Calcitonin Gene-Related Peptide, Placebo.

What condition does NCT03791515 study?

NCT03791515 studies Post-Traumatic Headache, Concussion, Mild.

Is NCT03791515 still recruiting?

NCT03791515 is currently completed. Last updated 29 January 2020.

Last reviewed 2020-01-29 · How we verify

NCT03791515

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Clinical Characteristics and Pathophysiology of Post-Traumatic Headache

Completed NA Last updated 29 January 2020

What this trial tests

NA trial testing Calcitonin Gene-Related Peptide in Post-Traumatic Headache in 200 participants. Completed in 1 December 2019.

Timeline

26 July 2018

Primary endpoint
1 December 2019

1 December 2019

Quick facts

Lead sponsor	Danish Headache Center
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	other
Enrollment	200
Start date	26 July 2018
Primary completion	1 December 2019
Estimated completion	1 December 2019
Sites	1 location across Denmark

Drugs / interventions tested

Calcitonin Gene-Related Peptide — full drug profile →
Placebo

Conditions studied

Post-Traumatic Headache — all drugs for Post-Traumatic Headache →
Concussion, Mild — all drugs for Concussion, Mild →

Sponsor

Danish Headache Center — full company profile →

Who can join

Adults 18 to 65, any sex, with Post-Traumatic Headache or Concussion, Mild. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

To better understand the clinical characteristics and complex pathophysiological events that constitute persistent post-traumatic headache (PPTH) and to identify possible calcitonin gene-related peptide (CGRP) hypersensitivity in PPTH patients.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Total tenderness score and pressure pain thresholds in persistent post-traumatic headache attributed to mild traumatic brain injury.
Ashina H, Al-Khazali HM, Iljazi A, Ashina S, et al · · 2022 · cited 8× · PMID 35941545 · DOI 10.1186/s10194-022-01457-1
Volume of the rectus capitis posterior minor muscle in migraine patients: a cross-sectional structural MRI study.
Hvedstrup J, Amin FM, Hougaard A, Ashina H, et al · · 2020 · cited 8× · PMID 32460751 · DOI 10.1186/s10194-020-01129-y
No evidence of intracranial hypotension in persistent post-traumatic headache: A magnetic resonance imaging study.
Schytz HW, Smilkov E, Carroll I, Dobrocky T, et al · · 2025 · cited 1× · PMID 40255022 · DOI 10.1177/03331024251325556
Pretreatment with an anti-CGRP monoclonal antibody attenuates mild TBI-induced tactile hypersensitivity in mice.
Wattiez AS, Kuburas A, Castonguay WC, Fejgin K, et al · · 2025 · PMID 40760469 · DOI 10.1186/s10194-025-02108-x

Verify or expand the search:

Other trials of Calcitonin Gene-Related Peptide

Trials testing the same drug.

NCT04592952 — Hypersensitivity to CGRP as a Predictive Biomarker of Migraine Prevention With Erenumab · Phase 4 · unknown

Other Danish Headache Center trials

Trials by the same sponsor.

NCT07451769 — Selective Activation of the Adrenomedullin Receptors in Migraine · NA · not yet recruiting
NCT07342296 — Induction of Migraine Attacks With Aura Using Pituitary Adenylate Cyclase Activating Polypeptide-38 · NA · not yet recruiting
NCT07059546 — Hypersensitivity to Adrenomedullin in Post-Traumatic Headache · NA · recruiting
NCT07021859 — Induction of Migraine Attacks With Aura Using Calcitonin Gene-Related Peptide · NA · recruiting
NCT06959004 — Substance P-Induced Migraine Attacks Without Aura · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03791515 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Danish Headache Center
Last refreshed: 29 January 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03791515.

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