NCT03786029 is a Phase 2, PHASE3 clinical trial of Acetaminophen in Local Anesthesia, sponsored by Tishreen University.

Who is sponsoring NCT03786029?

NCT03786029 is sponsored by Tishreen University.

What drugs are being tested in NCT03786029?

Interventions in NCT03786029: Acetaminophen, Placebo, Ibuprofen.

What condition does NCT03786029 study?

NCT03786029 studies Local Anesthesia, Tooth Extraction.

Is NCT03786029 still recruiting?

NCT03786029 is currently completed. Last updated 18 June 2019.

Last reviewed 2019-06-18 · How we verify

NCT03786029

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Pre-emptive Analgesic Administration in Primary Tooth Extraction

Completed Phase 2, PHASE3 Last updated 18 June 2019

What this trial tests

Phase 2, PHASE3 trial testing Acetaminophen in Local Anesthesia in 66 participants. Completed in 10 June 2019.

Timeline

1 April 2019

Primary endpoint
1 June 2019

10 June 2019

Quick facts

Lead sponsor	Tishreen University
Phase	Phase 2, PHASE3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	66
Start date	1 April 2019
Primary completion	1 June 2019
Estimated completion	10 June 2019
Sites	1 location across Syria

Drugs / interventions tested

Acetaminophen (Paracetamol) — full drug profile →
Placebo
Ibuprofen (ibuprofen) — full drug profile →

Conditions studied

Local Anesthesia — all drugs for Local Anesthesia →
Tooth Extraction — all drugs for Tooth Extraction →

Sponsor

Tishreen University

Who can join

Adults 6 to 8, any sex, with Local Anesthesia or Tooth Extraction. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Brief Summary: Aims: The objective of the current study will be to compare the effectiveness of Ibuprofen, Acetaminophen, and Placebo on reducing injection pain and post-operative pain in primary tooth extraction, and to compare the parents' satisfaction. Design: This will be a blinded, randomized placebo-controlled trial including sixty six cooperative children, aged 6-8 years old.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Ibuprofen for acute postoperative pain in children.
Pessano S, Gloeck NR, Tancredi L, Ringsten M, et al · · 2024 · cited 7× · PMID 38180091 · DOI 10.1002/14651858.cd015432.pub2
Comparison of preemptive ibuprofen, acetaminophen, and placebo administration in reducing peri- and postoperative pain in primary tooth extraction: A randomized clinical trial.
Raslan N, Zouzou T. · · 2021 · cited 6× · PMID 34121357 · DOI 10.1002/cre2.465

Verify or expand the search:

Other trials of Acetaminophen

Trials testing the same drug.

NCT07502001 — Influence of HDM1005 on Gastric Emptying and Pharmacokinetics of Metformin, Atorvastatin, Warfarin, and Digoxin · Phase 1 · not yet recruiting
NCT07525791 — A Research Study Looking Into How NNC0662-0419 Works With Birth Control Pills and Emptying of the Stomach in Women Not A · Phase 1 · not yet recruiting
NCT07508241 — A Study to Learn About the Effect of Study Medicine Called PF-08653944 on How Quickly the Stomach Empties Its Content in · Phase 1 · not yet recruiting
NCT06994442 — Optimizing Pain Treatment in Children On Mechanical Ventilation · Phase 3 · recruiting
NCT07101445 — Evaluating Premedication Regimens (Methylprednisolone vs Dexamethasone-based) for the Prevention of Systemic and Injecti · Phase 4 · recruiting

Other recruiting trials for Local Anesthesia

Currently open trials in the same condition.

NCT07449884 — AI Avatar Video vs. Tell-Show-Do for Reducing Anxiety and Improving Cooperation in Children During Local Anesthesia · NA · recruiting
NCT06346132 — Effect of Virtual Reality on Patient's Comfort During Cardiac Electronic Device Implantation. · NA · recruiting
NCT04708808 — The Effect of Music Therapy Under Ultrasound Guided Manual Vacuum Aspiration · NA · recruiting

Other Tishreen University trials

Trials by the same sponsor.

NCT07350421 — The Effectiveness of Inhaled Salbutamol in the Management of Transient Tachypnea of the Newborn(TTN) · NA · not yet recruiting
NCT07270042 — Evaluation the Efficacy of Zinc on Botulinum Toxin A Injection · NA · not yet recruiting
NCT07099261 — A Comparative Clinical Study to Evaluate Crowns Designed by Artificial Intelligence Versus Crowns Designed Traditional D · NA · not yet recruiting
NCT07467759 — Benzydamine for Radiation-Induced Oral Mucositis in Patients Receiving High-Dose Radiotherapy · Phase 4 · completed
NCT07095946 — Effectiveness of Intraligament vs IANB Anesthesia in Children Using Electronic Syringe · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03786029 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Tishreen University
Last refreshed: 18 June 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03786029.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing