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NCT03769142

Cerebral Perfusion During Induction of General Anesthesia

Completed Last updated 7 December 2018
What this trial tests

trial testing All monitoring in Radiography in 100 participants. Completed in 1 December 2016.

Timeline
1 February 2014
Primary endpoint
1 December 2016
1 December 2016

Quick facts

Lead sponsorAssistance Publique - Hôpitaux de Paris
StatusCompleted
Study typeOBSERVATIONAL
Enrollment100
Start date1 February 2014
Primary completion1 December 2016
Estimated completion1 December 2016

Drugs / interventions tested

Conditions studied

Sponsor

Assistance Publique - Hôpitaux de Paris — full company profile →

Who can join

18 and older, any sex, with Radiography or Interventional. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Arterial hypotension during general anesthesia remains a factor of poor outcomes, increases the risk of myocardial infarction, acute kidney injury and 1-year mortality. Furthermore, arterial hypotension may also decrease cerebral perfusion contributing to worsen neurological outcome. It seems necessary to monitor cerebral perfusion during anesthesia and to define individual dynamic targets of blood pressure. The goal of this study is to evaluate cerebral perfusion change in adult patients with or without cardiovascular risk factors during a standardized propofol-remifentanil anesthesia induction. Cerebral perfusion will be evaluated and compared using the simultaneously measure of TCD, NIRS and BIS. Those measures will be also repeated during and after treatment of arterial hypotension episodes in both groups.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. Impact of impaired cerebral blood flow autoregulation on electroencephalogram signals in adults undergoing propofol anaesthesia: a pilot study.
    Manquat E, Ravaux H, Kindermans M, Joachim J, et al · · 2022 · cited 7× · PMID 37588691 · DOI 10.1016/j.bjao.2022.100004

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Other trials of All monitoring

Trials testing the same drug.

Other recruiting trials for Radiography

Currently open trials in the same condition.

Other Assistance Publique - Hôpitaux de Paris trials

Trials by the same sponsor.

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