Who is sponsoring NCT03752749?

NCT03752749 is sponsored by Shirley Ryan AbilityLab.

What drugs are being tested in NCT03752749?

Interventions in NCT03752749: Prednisolone + Acute Intermittent Hypoxia, Placebo + Acute Intermittent Hypoxia.

What condition does NCT03752749 study?

NCT03752749 studies Spinal Cord Injuries.

Is NCT03752749 still recruiting?

NCT03752749 is currently completed. Last updated 26 November 2018.

Last reviewed 2018-11-26 · How we verify

NCT03752749

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Impact of Intermittent Hypoxia and Prednisolone on Motor Performance in Persons With SCI

Completed NA Last updated 26 November 2018

What this trial tests

NA trial testing Prednisolone + Acute Intermittent Hypoxia in Spinal Cord Injuries in 14 participants. Completed in 1 December 2016.

Timeline

1 December 2014

Primary endpoint
1 December 2016

1 December 2016

Quick facts

Lead sponsor	Shirley Ryan AbilityLab
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	treatment
Enrollment	14
Start date	1 December 2014
Primary completion	1 December 2016
Estimated completion	1 December 2016

Drugs / interventions tested

Prednisolone + Acute Intermittent Hypoxia
Placebo + Acute Intermittent Hypoxia

Conditions studied

Spinal Cord Injuries — all drugs for Spinal Cord Injuries →

Sponsor

Shirley Ryan AbilityLab — full company profile →

Who can join

Adults 18 to 65, any sex, with Spinal Cord Injuries. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The objective of this study is to examine the effects of mild acute intermittent hypoxia (AIH) in combination with an anti-inflammatory drug (i.e. prednisolone) on motor performance in persons with spinal cord injury (SCI).

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Prednisolone Pretreatment Enhances Intermittent Hypoxia-Induced Plasticity in Persons With Chronic Incomplete Spinal Cord Injury.
Sandhu MS, Gray E, Kocherginsky M, Jayaraman A, et al · · 2019 · cited 40× · PMID 31524075 · DOI 10.1177/1545968319872992
Combining Therapeutic Strategies to Treat the Injured Spinal Cord: A Translational Perspective.
Sherman BC, Schmidt Read M, Hoh DJ, Guest JD, et al · · 2025 · cited 2× · PMID 40929022 · DOI 10.1177/08977151251371710

Verify or expand the search:

Other recruiting trials for Spinal Cord Injuries

Currently open trials in the same condition.

NCT07109804 — Cuneiform Nucleus (CnF) Deep Brain Stimulation for Gait Facilitation Following Spinal Cord Injury · NA · recruiting
NCT07472985 — Protocol for Rapid Onset of Mobilization in Patients With Traumatic Spinal Cord Injury II (PROMPT-SCI II) Trial · NA · recruiting
NCT07210411 — Acute and Chronic Repercussion of Spinal Cord Stimulation After Spinal Cord Injury · NA · recruiting
NCT07488793 — Remote Ischemic Conditioning for PwSCI · NA · recruiting
NCT07536386 — Self-balancing Personal Exoskeleton for SCI (WIP) · NA · recruiting

Other Shirley Ryan AbilityLab trials

Trials by the same sponsor.

NCT07434492 — Smart AFO and 5-Azacitidine to Enhance Mobility in Children With Cerebral Palsy · Phase 2 · not yet recruiting
NCT07433023 — tSCS and 5-Azacitidine for Enhanced Motor Outcomes in Cerebral Palsy · Phase 2 · not yet recruiting
NCT06999213 — Lower Limb ExoNET: Development and Evaluation for Gait Assistance With Stroke Survivors · EARLY_PHASE1 · not yet recruiting
NCT07032753 — Neuromusculoskeletal Interface for Bionic Arms · NA · not yet recruiting
NCT07223710 — Improving Walking After Spinal Cord Injury · Phase 1, PHASE2 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03752749 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Shirley Ryan AbilityLab
Last refreshed: 26 November 2018

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03752749.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing