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NCT07223710
Improving Walking After Spinal Cord Injury
Phase 1, PHASE2 trial testing Paired Associative Stimulation in Spinal Cord Injury in 20 participants. Not yet recruiting.
30 March 2026
Quick facts
| Lead sponsor | Shirley Ryan AbilityLab |
|---|---|
| Phase | Phase 1, PHASE2 |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 20 |
| Start date | 15 November 2025 |
| Primary completion | 30 March 2026 |
| Estimated completion | 30 July 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Paired Associative Stimulation
- Locomotor Training
- Sham stimulation
Conditions studied
- Spinal Cord Injury — all drugs for Spinal Cord Injury →
Sponsor
Shirley Ryan AbilityLab — full company profile →
Who can join
Adults 18 to 75, any sex, with Spinal Cord Injury. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Locomotor recovery is one of the most important goals of individuals with spinal cord injury (SCI). Ambulatory deficits severely impact daily functions resulting in lower quality of life for people living with paralysis due to SCI. Although studies have shown that locomotor training improves locomotor function in people with chronic SCI, the benefits remain limited. Our overall hypothesis is that we can engage additional descending motor pathways, such as the reticulospinal tract (RST), to improve locomotor function in humans with chronic incomplete SCI. In this study we propose to test the effects of a novel intervention that uses repeated paired loud auditory and electrical stimulation of muscle afferents combined with locomotor training on walking speed and voluntary muscle strength.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07223710
- Europe PMC full search
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Related trials
Other trials of Paired Associative Stimulation
Trials testing the same drug.
- NCT04784832 — TMS-based Assessment of Mental Training Effects on Motor Learning in Healthy Participants · NA · recruiting
Other recruiting trials for Spinal Cord Injury
Currently open trials in the same condition.
- NCT07429305 — Combined Tibial Nerve Stimulation and Standing for People With SCI · NA · recruiting
- NCT06410001 — CE-STAND: Cervical Epidural STimulation After Neurologic Damage · Phase 1, PHASE2 · recruiting
- NCT05926596 — Leg Stretching Using an Exoskeleton on Demand for People With Spasticity · NA · recruiting
- NCT06839300 — The International Spinal Cord Injury Blood Biomarker Longitudinal Evaluation (I-SCRIBBLE) Study · recruiting
- NCT07036107 — A Trial on the Clinical and Socioeconomic Impact of Wearable Exoskeletons for Spinal Cord Injury Rehabilitation in the S · NA · recruiting
Other Shirley Ryan AbilityLab trials
Trials by the same sponsor.
- NCT07434492 — Smart AFO and 5-Azacitidine to Enhance Mobility in Children With Cerebral Palsy · Phase 2 · not yet recruiting
- NCT07433023 — tSCS and 5-Azacitidine for Enhanced Motor Outcomes in Cerebral Palsy · Phase 2 · not yet recruiting
- NCT06999213 — Lower Limb ExoNET: Development and Evaluation for Gait Assistance With Stroke Survivors · EARLY_PHASE1 · not yet recruiting
- NCT07032753 — Neuromusculoskeletal Interface for Bionic Arms · NA · not yet recruiting
- NCT07364773 — Enhancing Rehabilitation Participation in Patients With SCI/D Using Motivational Interviewing · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07223710 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Shirley Ryan AbilityLab
- Last refreshed: 3 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07223710.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing