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NCT03694717: TCCO
Time Course Evolution of Cardiac Output
trial testing Saline Solution for Injection in Acute Circulatory Failure in 58 participants. Completed in 31 May 2018.
15 May 2018
Quick facts
| Lead sponsor | Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 58 |
| Start date | 15 April 2016 |
| Primary completion | 15 May 2018 |
| Estimated completion | 31 May 2018 |
Drugs / interventions tested
- Saline Solution for Injection — full drug profile →
Conditions studied
- Acute Circulatory Failure — all drugs for Acute Circulatory Failure →
Sponsor
Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil
Who can join
Adults 18 to 99, any sex, with Acute Circulatory Failure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Fluid expansion is the first therapeutic option in patients presenting acute circulatory failure but the duration of its hemodynamic effects (persistency and time of maximal increase in cardiac output) is unknown. This study is seeking to describe in critically ill patients, the time course evolution of cardiac output over a 2-hours period after a fluid expansion. The objectives are: 1. to identify patterns of fluid responsiveness 2. to determine the time when the maximal increase in cardiac output occurs during and a after fluid expansion 3. to compare patients' characteristics between patterns Patients with acute circulatory failure will be recruited as soon as a fluid expansion will be decided by the physician in charge and the effects of fluid expansion on hemodynamic indices (cardiac output, arterial pressure) will be continuously recorded through a transpulmonary thermodilution device over a 2-hours period. No changes in ventilatory settings nor vasopressors or sedatives will be allowed during the study. Patients will be categorized into patterns according to the changes in cardiac output after fluid expansion and their characteristics will be compared.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03694717
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil trials
Trials by the same sponsor.
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- NCT04098094 — Outcomes of RV Dysfunction in Acute Exacerbation of Chronic Respiratory Diseases · unknown
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03694717 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil
- Last refreshed: 4 October 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03694717.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing