Who is sponsoring NCT03874936?

NCT03874936 is sponsored by Odense University Hospital.

What drugs are being tested in NCT03874936?

Interventions in NCT03874936: Dexamethasone 24mg Solution for Injection, Saline Solution for Injection.

What condition does NCT03874936 study?

NCT03874936 studies Dexamethasone, Hip Dysplasia, Postoperative Pain, Postoperative Nausea and Vomiting.

Is NCT03874936 still recruiting?

NCT03874936 is currently completed. Last updated 2 April 2024.

Last reviewed 2024-04-02 · How we verify

NCT03874936: PAODEX

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Effect of Perioperative Dexamethasone Administration on Postoperative Pain in Patients Undergoing Periacetabular Osteotomy.

Completed Phase 2, PHASE3 Last updated 2 April 2024

What this trial tests

Phase 2, PHASE3 trial testing Dexamethasone 24mg Solution for Injection in Dexamethasone in 90 participants. Completed in 31 December 2023.

Timeline

12 November 2020

Primary endpoint
31 December 2022

31 December 2023

Quick facts

Lead sponsor	Odense University Hospital
Phase	Phase 2, PHASE3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	prevention
Enrollment	90
Start date	12 November 2020
Primary completion	31 December 2022
Estimated completion	31 December 2023
Sites	1 location across Denmark

Drugs / interventions tested

Dexamethasone 24mg Solution for Injection — full drug profile →
Saline Solution for Injection — full drug profile →

Conditions studied

Dexamethasone — all drugs for Dexamethasone →
Hip Dysplasia — all drugs for Hip Dysplasia →
Postoperative Pain — all drugs for Postoperative Pain →
Postoperative Nausea and Vomiting — all drugs for Postoperative Nausea and Vomiting →

Sponsor

Odense University Hospital

Who can join

18 and older, any sex, with Dexamethasone or Hip Dysplasia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is an investigator-initiated, Danish mono-center, randomized, placebo-controlled, parallel group, double-blind, superiority trial of dexamethasone on postoperative pain management on patients undergoing operation for hip dysplasia with the periacetabular osteotomy procedure (PAO). 90 adults undergoing PAO will be enrolled. The primary outcome is to compare the effect of dexamethasone relative to placebo on cumulated postoperative morphine consumption at 48 hours. Key secondary outcomes include comparing the effect of repeated doses of dexamethasone relative to a single dose on cumulated postoperative morphine consumption at 48 hours, and to determine if dexamethasone is superior to placebo for: Perception of pain intensity, prevalence and degree of postoperative nausea and vomiting, and patient-reported outcome measures.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis.
Weibel S, Rücker G, Eberhart LH, Pace NL, et al · · 2020 · cited 125× · PMID 33075160 · DOI 10.1002/14651858.cd012859.pub2
Effect of high-dose dexamethasone on morphine use after periacetabular osteotomy for hip dysplasia: a randomized double-blind placebo-controlled single center trial.
Lindberg-Larsen V, Lindberg-Larsen M, Ovesen O, Zwisler ST, et al · · 2025 · PMID 40460271 · DOI 10.2340/17453674.2025.43903

Verify or expand the search:

Other recruiting trials for Dexamethasone

Currently open trials in the same condition.

NCT07086118 — Dexamethasone Versus Metoclopramide for Prophylaxis of Nausea and Vomiting After Cataract Surgery · NA · recruiting
NCT06980870 — Effect of Pre-medication With Anti-inflammatory Drugs(Ibuprofen and Dexamethasone)on Post-Endodontic Pain · Phase 2 · recruiting
NCT06262893 — Effect of Dexamethasone Adjuvant in Combined Supraclavicular Block and Suprascapular Block Versus Interscalene Block in · NA · recruiting
NCT07139522 — Dexamethasone Versus Magnesium Sulphate as an Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Plane Block fo · NA · recruiting
NCT06133712 — Dexmedetomidine, Ozone and Dexamethasone Local Injection in Carpal Tunnel Syndrome for Pain Relief · NA · recruiting

Other Odense University Hospital trials

Trials by the same sponsor.

NCT07163091 — Bracing After Ankle Fracture · NA · not yet recruiting
NCT07521696 — Physical Recovery During Bracing After Ankle Fracture (Re-BAF) · NA · not yet recruiting
NCT07466212 — QoLIDia: Quality of Life in Cancer Patients With Diabetes During Immunotherapy · not yet recruiting
NCT07191379 — Self-administered Subcutaneous Daratumumab in Patients With Multiple Myeloma · Phase 4 · not yet recruiting
NCT07170085 — Positioning of Children With Acute Respiratory Insufficiency · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03874936 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Odense University Hospital
Last refreshed: 2 April 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03874936.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing