NCT03668964 (VitaGut) is a NA clinical trial of Vitamin B2 in Healthy Volunteers, sponsored by dsm-firmenich Switzerland AG.

Who is sponsoring NCT03668964?

NCT03668964 is sponsored by dsm-firmenich Switzerland AG.

What drugs are being tested in NCT03668964?

Interventions in NCT03668964: Vitamin B2, Vitamin C, Vitamin B2 + C, Vitamin A, Vitamin D3, Vitamin E, Placebo.

What condition does NCT03668964 study?

NCT03668964 studies Healthy Volunteers.

Is NCT03668964 still recruiting?

NCT03668964 is currently completed. Last updated 30 March 2020.

Last reviewed 2020-03-30 · How we verify

NCT03668964: VitaGut

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Nutrition Ingredients on Microbiota Modulation

Completed NA Last updated 30 March 2020

What this trial tests

NA trial testing Vitamin B2 in Healthy Volunteers in 96 participants. Completed in 15 July 2019.

Timeline

20 August 2018

Primary endpoint
15 July 2019

15 July 2019

Quick facts

Lead sponsor	dsm-firmenich Switzerland AG
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	basic science
Enrollment	96
Start date	20 August 2018
Primary completion	15 July 2019
Estimated completion	15 July 2019
Sites	1 location across Ireland

Drugs / interventions tested

Vitamin B2
Vitamin C — full drug profile →
Vitamin B2 + C
Vitamin A — full drug profile →
Vitamin D3 (cholecalciferol) — full drug profile →
Vitamin E (VITAMIN E) — full drug profile →
Placebo

Conditions studied

Healthy Volunteers — all drugs for Healthy Volunteers →

Sponsor

dsm-firmenich Switzerland AG — full company profile →

Who can join

Adults 20 to 50, any sex, with Healthy Volunteers. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The objective of this study is to evaluate in healthy volunteers the time-dependent effect of daily consumption for four weeks of six different nutrition ingredients on relative abundance of microbial taxa in fecal samples. Second, the study looks at the time-dependent effect of six different nutrition ingredients on alpha and beta diversity of microbiota in fecal samples. Moreover, the time-dependent effect of six different nutrition ingredients on gastrointestinal symptoms and quality of life will be measured.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Effects of colon-targeted vitamins on the composition and metabolic activity of the human gut microbiome- a pilot study.
Pham VT, Fehlbaum S, Seifert N, Richard N, et al · · 2021 · cited 106× · PMID 33615992 · DOI 10.1080/19490976.2021.1875774

Verify or expand the search:

Other recruiting trials for Healthy Volunteers

Currently open trials in the same condition.

NCT07504003 — Influence of Training Session Duration on Improvements in Physiological Resilience to Exercise · NA · recruiting
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NCT07342114 — A Dose-Escalation Study of RO7875913 in Healthy Participants · Phase 1 · recruiting

Other dsm-firmenich Switzerland AG trials

Trials by the same sponsor.

NCT06889779 — Study Evaluating the Efficacy of Different Mixes of HMO-2FL + Humiome® Post LB on IBS Gastrointestinal Symptoms · NA · recruiting
NCT06425081 — Investigating the Impact of Humiome B2 (Colon Delivered Riboflavin) and Riboflavin-overproducer Probiotic Strain Limosil · NA · completed
NCT06578455 — A Pharmacokinetic Study to Compare CBD-NE to Epidyolex in Healthy Adult Volunteers Under Both Fed and Fasted Conditions · Phase 1 · completed
NCT06471023 — A Pharmacokinetic Study of Single Oral Doses of Six Different Vitamin C Product Forms · NA · completed
NCT05205785 — Human Milk Oligosaccharides (HMOs) for Irritable Bowel Syndrome (IBS) · NA · terminated

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03668964 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by dsm-firmenich Switzerland AG
Last refreshed: 30 March 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03668964.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing