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NCT03551574
Adaptive Optics in PVR
trial in Retinal Detachment in 25 participants. Completed in 4 June 2018.
4 June 2018
Quick facts
| Lead sponsor | Moorfields Eye Hospital NHS Foundation Trust |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 25 |
| Start date | 13 April 2017 |
| Primary completion | 4 June 2018 |
| Estimated completion | 4 June 2018 |
| Sites | 1 location across United Kingdom |
Conditions studied
- Retinal Detachment — all drugs for Retinal Detachment →
Sponsor
Moorfields Eye Hospital NHS Foundation Trust
Who can join
18 and older, any sex, with Retinal Detachment. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to investigate the loss of retinal cells following retinal detachment surgery using an imaging device called an adaptive optics camera. The retina is a thin layer which lines the back of the eye. It is sensitive to light (like the film in a camera) and is necessary for vision. If a hole or rip develops in a retina it can become detached. The macula is the central portion of the retina which the investigators use for fine vision. This area can also become detached as part of a retinal detachment. Proliferative vitreoretinopathy (PVR) is an abnormal scarring response inside the eye which can occur when the retina detaches. It can adversely affect the outcome of the retinal detachment repair and is associated with a worse visual prognosis. The investigators want to investigate retinal cell loss in patients with retinal detachments that have developed PVR when the macula has been involved. The investigators plan to compare them to two other groups of patients, who have not developed PVR: 1. Patients with macula-involving retinal detachments without PVR 2. Patients with macula-sparing detachments without PVR The investigators will investigate retinal cell loss in these types of retinal detachments using adaptive optics imaging. This is a non-invasive imaging technique which allows the investigators to view the retina at very high magnification. Investigating photoreceptor loss and its association with visual outcome in this way should help to guide future interventions in promoting retinal regeneration. The investigators plan to recruit 25 patients at one UK hospital. The project is funded by the charity Fight for Sight.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03551574
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Related trials
Other recruiting trials for Retinal Detachment
Currently open trials in the same condition.
- NCT06587945 — Nicotinamide Riboside Oral Supplementation in Macula Off Retinal Detachment · Phase 4 · recruiting
- NCT06985030 — Head Position Monitoring After Pars Planar Vitrectomy · active not recruiting
- NCT06830070 — Subjective Pain Scoring for Subtenonal Anesthesia During Vitrectomy · active not recruiting
- NCT03713268 — Intraoperative OCT Guidance of Intraocular Surgery II · recruiting
Other Moorfields Eye Hospital NHS Foundation Trust trials
Trials by the same sponsor.
- NCT06974162 — Metagenomics for Ocular Inflammation · recruiting
- NCT06689397 — Investigating Epstein-Barr Virus Associated Conjunctivitis · enrolling by invitation
- NCT06528509 — AI-Enhanced Consent for Cataract Surgery · NA · not yet recruiting
- NCT03102138 — Retinal Pigment Epithelium Safety Study for Patients in B4711001 · active not recruiting
- NCT05543889 — Evaluation of Clinical Decisions and Assessment of Those at Risk of Primary Angle Closure by Community Optometrists · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03551574 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Moorfields Eye Hospital NHS Foundation Trust
- Last refreshed: 9 September 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03551574.
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