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NCT06974162
Metagenomics for Ocular Inflammation
trial testing Metagenomic sequencing of aqueous humor in Uveitis in 36 participants. Currently enrolling.
12 June 2026
Quick facts
| Lead sponsor | Moorfields Eye Hospital NHS Foundation Trust |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 36 |
| Start date | 12 June 2025 |
| Primary completion | 12 June 2026 |
| Estimated completion | 12 July 2026 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Metagenomic sequencing of aqueous humor
- Ocular Imaging
Conditions studied
- Uveitis — all drugs for Uveitis →
- Aqueous Humor — all drugs for Aqueous Humor →
- Infection — all drugs for Infection →
Sponsor
Moorfields Eye Hospital NHS Foundation Trust
Who can join
Eligibility, any sex, with Uveitis or Aqueous Humor. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of this study is to apply a diagnostic test called 'metagenomic sequencing' to identify the involvement of potential infections in patients with ocular inflammation, where this hasn't been detected by currently available standard testing. For many people with ocular inflammation, no cause is ever found for their disease. In some cases, an infection or infectious trigger is suspected, but currently available tests are inadequate. Metagenomic sequencing can identify almost every globally known infection (bacteria, virus, fungi, parasites) in a sample. Therefore, it has the potential to identify an infection that has caused or triggered ocular inflammation, and as a consequence may help to identify specific treatments. It has the potential to improve our understanding of how to diagnose and treat people with this problem. This study will allow us to test the technique that has been previously optimised for brain infections, on ocular fluids. Participants will be 18 years of age or over and have active ocular inflammation which is suspected to be due to an infection, or an autoimmune process which has been triggered by an infection, but identification of this infection has not been possible using the investigations available as part of standard NHS care. Participants will be identified by the treating clinical team as requiring a sample of fluid from inside of the eye, and some of this fluid will be sent for metagenomic sequencing alongside standard testing. This study will be conducted at Moorfields Eye Hospital, London and will last for approximately a year. Participants will undergo additional non-invasive ocular imaging on the day of their clinic visit, but will not have to attend any additional research visits.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06974162
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Uveitis
Currently open trials in the same condition.
- NCT07262437 — Targeting Immunosuppressive Treatment for Non-infectious Uveitis Using Aqueous Humor Cytokine Profiles · NA · active not recruiting
- NCT07176130 — Demographics and Clinical Characteristics of Ocular Inflammatory Diseases in Singapore · active not recruiting
- NCT06431373 — A Study of Brepocitinib in Adults With Active, Non-Infectious, Non-Anterior Uveitis · Phase 3 · active not recruiting
- NCT06310837 — Effect of Immunosuppressants With Adalimumab Biosimilars vs Corticosteroids on Noninfectious Uveitis · NA · active not recruiting
- NCT05727540 — The Cohort Study of Uveitis Patients · recruiting
Other Moorfields Eye Hospital NHS Foundation Trust trials
Trials by the same sponsor.
- NCT06689397 — Investigating Epstein-Barr Virus Associated Conjunctivitis · enrolling by invitation
- NCT06528509 — AI-Enhanced Consent for Cataract Surgery · NA · not yet recruiting
- NCT03102138 — Retinal Pigment Epithelium Safety Study for Patients in B4711001 · active not recruiting
- NCT05543889 — Evaluation of Clinical Decisions and Assessment of Those at Risk of Primary Angle Closure by Community Optometrists · unknown
- NCT05313516 — OKKO Space Academy to Check Children's Vision at Home · NA · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06974162 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Moorfields Eye Hospital NHS Foundation Trust
- Last refreshed: 20 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06974162.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing