NCT03528434 (ZIPS) is a NA clinical trial of Zinc in Sickle Cell Disease, sponsored by Indiana University.

Who is sponsoring NCT03528434?

NCT03528434 is sponsored by Indiana University.

What drugs are being tested in NCT03528434?

Interventions in NCT03528434: Zinc, Placebo.

What condition does NCT03528434 study?

NCT03528434 studies Sickle Cell Disease.

Is NCT03528434 still recruiting?

NCT03528434 is currently completed. Last updated 9 February 2021.

Last reviewed 2021-02-09 · How we verify

NCT03528434: ZIPS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Zinc for Infection Prevention in Sickle Cell Anemia (ZIPS)

Completed NA Last updated 9 February 2021

What this trial tests

NA trial testing Zinc in Sickle Cell Disease in 250 participants. Completed in 23 November 2020.

Timeline

14 March 2019

Primary endpoint
23 November 2020

23 November 2020

Quick facts

Lead sponsor	Indiana University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	prevention
Enrollment	250
Start date	14 March 2019
Primary completion	23 November 2020
Estimated completion	23 November 2020
Sites	1 location across Uganda

Drugs / interventions tested

Zinc — full drug profile →
Placebo

Conditions studied

Sickle Cell Disease — all drugs for Sickle Cell Disease →

Sponsor

Indiana University

Who can join

Adults 1 to 5, any sex, with Sickle Cell Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A randomized double-blinded placebo-controlled trial of zinc to reduce the incidence of severe or invasive infections in Ugandan children with sickle cell anemia (SCA).

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

Hydroxyurea reduces infections in children with sickle cell anemia in Uganda.
Namazzi R, Bond C, Conroy AL, Datta D, et al · · 2024 · cited 16× · PMID 38169476 · DOI 10.1182/blood.2023021575
Zinc for infection prevention in children with sickle cell anemia: a randomized double-blind placebo-controlled trial.
Namazzi R, Opoka R, Conroy AL, Datta D, et al · · 2023 · cited 10× · PMID 36735400 · DOI 10.1182/bloodadvances.2022008539
Zinc for Infection Prevention in Sickle Cell Anemia (ZIPS): study protocol for a randomized placebo-controlled trial in Ugandan children with sickle cell anemia.
Datta D, Namazzi R, Conroy AL, Cusick SE, et al · · 2019 · cited 8× · PMID 31349866 · DOI 10.1186/s13063-019-3569-z
Pharmacokinetic-Guided Hydroxyurea to Reduce Transfusions in Ugandan Children with Sickle Cell Anemia: Study Design of the Alternative Dosing And Prevention of Transfusions Trial.
Power-Hays A, Namazzi R, Kato C, McElhinney KE, et al · · 2025 · cited 5× · PMID 38824918 · DOI 10.1159/000539541
The 4th Global Congress on Sickle Cell Disease Abstract Book 2022
· 2022
PI-08: HIGH DISEASE BURDEN, MORBIDITY AND MORTALITY AMONG CHILDREN WITH SICKLE CELL ANAEMIA IN UGANDA
R. N, A. C, C. B, M. G, et al · · 2022
Impact of a National Lockdown for COVID-19 on Morbidity and Mortality Among Children with Sickle Cell Anaemia at a Tertiary Care Hospital in Uganda
Namazzi R, Opoka R, Conroy A, Datta D, et al · · 2020
Zinc for Infection Prevention in Sickle Cell Anemia (ZIPS): Study Protocol for a Randomized Placebo-Controlled Trial in Ugandan children with Sickle Cell Anemia
Datta D, Namazzi R, Conroy AL, Cusick SE, et al · · 2019 · DOI 10.21203/rs.2.377/v2

Verify or expand the search:

Other trials of Zinc

Trials testing the same drug.

NCT06664008 — The Effect of Probiotic and Zinc Supplementation in Patients With Gastroesophageal Reflux Disease · Phase 4 · not yet recruiting
NCT06540209 — Comparison of Effectiveness of Zinc Supplementation With ORS and Bacillus Clausii Versus Zinc With ORS and Saccharomyces · NA · completed
NCT05785013 — The Impact of Preoperative Supplementation of Zinc · NA · completed
NCT05212480 — Evaluation of the Efficacy and Safety of Zinc in Viral Infections · NA · completed
NCT05453227 — Zinc Containing Vaginal Topical " Suppository " · Phase 1, PHASE2 · completed

Other recruiting trials for Sickle Cell Disease

Currently open trials in the same condition.

NCT07369024 — Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young Adults · Phase 2 · recruiting
NCT06016634 — Alendronate for Osteonecrosis in Adults With Sickle Cell Disease · Phase 2 · recruiting
NCT06260891 — Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones Trial · Phase 2 · recruiting
NCT07222475 — Writing Relaxing Beats in Adolescents Who Have Sickle Cell Disease · NA · recruiting
NCT07224360 — Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD) · Phase 2 · recruiting

Other Indiana University trials

Trials by the same sponsor.

NCT07470086 — The Role of Environmental Temperatures in Respiratory Control · NA · not yet recruiting
NCT07470099 — The Role of Breathing Perception in Respiratory Control · NA · not yet recruiting
NCT07179952 — Efficacy and Safety of Slow Release Dehydroepiandrosterone (DHEA ) · Phase 2 · not yet recruiting
NCT07070804 — Maternal Biomarkers and Environmental Contributors to Autism Spectrum Disorders in Children of First-time Mothers · not yet recruiting
NCT07499583 — Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder · Phase 1, PHASE2 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03528434 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Indiana University
Last refreshed: 9 February 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03528434.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing