NCT03525470 is a NA clinical trial of Water in Hydration, sponsored by Swansea University.

Who is sponsoring NCT03525470?

NCT03525470 is sponsored by Swansea University.

What drugs are being tested in NCT03525470?

Interventions in NCT03525470: Water, No drink.

Is NCT03525470 still recruiting?

NCT03525470 is currently completed. Last updated 15 May 2018.

Last reviewed 2018-05-15 · How we verify

NCT03525470

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Autonomic Adaptations to Hydration and Brain Functioning

Completed NA Last updated 15 May 2018

What this trial tests

NA trial testing Water in Hydration in 12 participants. Completed in 1 April 2018.

Timeline

1 January 2016

Primary endpoint
1 April 2018

1 April 2018

Quick facts

Lead sponsor	Swansea University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	basic science
Enrollment	12
Start date	1 January 2016
Primary completion	1 April 2018
Estimated completion	1 April 2018

Drugs / interventions tested

Water (WATER) — full drug profile →
No drink

Conditions studied

Hydration — all drugs for Hydration →

Sponsor

Swansea University

Who can join

Adults 20 to 30, male only, with Hydration. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The influence of relatively small decreases in hydration status have been little studied. On two occasions subjects will be allowed to lose about 0,5% of their body weight and one occasion 300ml of water will be consumed. Functional MRI will be used to monitor brain functioning when performing a mental arithmetic task. Heart rate variability will be monitored and related to differences in brain functioning when water has and has not been drunk

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Autonomic adaptations mediate the effect of hydration on brain functioning and mood: Evidence from two randomized controlled trials.
Young HA, Cousins A, Johnston S, Fletcher JM, et al · · 2019 · cited 16× · PMID 31712590 · DOI 10.1038/s41598-019-52775-5
Autonomic Adaptations mediate the effect of Hydration on Brain Functioning, Cognition and Mood: A Randomised Controlled Trial.
Young HA, Benton D. · · 2018 · DOI 10.31234/osf.io/uzthx

Verify or expand the search:

Other trials of Water

Trials testing the same drug.

NCT07367139 — Occupational Exposure to Whole Body Vibration Among U.S. Military Veterans: Acute and Chronic Contributions to Musculosk · NA · not yet recruiting
NCT07507344 — Beverage Hydration Index of Different Solutions · NA · recruiting
NCT07439198 — The Influence of Water Intake on Food Intake at Meals Varying in Moisture · NA · not yet recruiting
NCT07459413 — Oral vs. Intravenous Hydration to Prevent Contrast-Associated Acute Kidney Injury in the ED · NA · recruiting
NCT07361887 — Deciphering the Effect of Moderate Wine Consumption on Healthy Aging Through Postprandial Extracellular Vesicles. · NA · recruiting

Other recruiting trials for Hydration

Currently open trials in the same condition.

NCT07507344 — Beverage Hydration Index of Different Solutions · NA · recruiting
NCT07005895 — Feasibility of Using the Gatorade Sports Science Institute (GSSI) Labs App for Hydration Related Outcomes · recruiting
NCT03823820 — Bioimpedance In Pregnancy and Labour: A Fluid Balance Concept Study. · recruiting

Other Swansea University trials

Trials by the same sponsor.

NCT07452562 — Hesperidin RCT in MS · NA · recruiting
NCT07272096 — ACTing Minds: An ACT-based Videogame for Mental Health · NA · completed
NCT06961513 — Patient Evaluation of Treatment of Pelvic-floor Muscle Dysfunction. · not yet recruiting
NCT06698588 — Symptom-specific Effects of Omega-3 Across Neurodevelopmental Symptoms · NA · recruiting
NCT06407557 — Optimizing Older Adults' Home Space for Physical Activity · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03525470 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Swansea University
Last refreshed: 15 May 2018

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03525470.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing