NCT03512730 is a Phase 2 clinical trial of Titanium brush in Peri-Implantitis, sponsored by Universitat Internacional de Catalunya.

Who is sponsoring NCT03512730?

NCT03512730 is sponsored by Universitat Internacional de Catalunya.

What drugs are being tested in NCT03512730?

Interventions in NCT03512730: Titanium brush, Classic decontamination.

What condition does NCT03512730 study?

NCT03512730 studies Peri-Implantitis.

Is NCT03512730 still recruiting?

NCT03512730 is currently completed. Last updated 4 May 2018.

Last reviewed 2018-05-04 · How we verify

NCT03512730

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

A NEW MECHANICAL DECONTAMINATION METHOD IN PERI-IMPLANTITIS, TI-BRUSH, A RANDOMIZED CONTROLLED CLINICAL TRIAL

Completed Phase 2 Last updated 4 May 2018

What this trial tests

Phase 2 trial testing Titanium brush in Peri-Implantitis in 30 participants. Completed in 20 June 2017.

Timeline

19 November 2013

Primary endpoint
10 December 2013

20 June 2017

Quick facts

Lead sponsor	Universitat Internacional de Catalunya
Phase	Phase 2
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	30
Start date	19 November 2013
Primary completion	10 December 2013
Estimated completion	20 June 2017

Drugs / interventions tested

Titanium brush
Classic decontamination

Conditions studied

Peri-Implantitis — all drugs for Peri-Implantitis →

Sponsor

Universitat Internacional de Catalunya — full company profile →

Who can join

Adults 18 to 90, any sex, with Peri-Implantitis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Objective: The objective of this study was to evaluate a new mechanical method (Ti-Brush, Straumann, AG, Basel, Switzerland) of implant surface decontamination. Material and methods: A randomized double-blinded controlled clinical trial with a 1-year follow-up it is being carried out. After a hygienic phase, defects were randomly assigned to a control (n=18) or to a test group (n=18). In control group, implant surface was decontaminated both mechanically and chemically with 3% H2O2 and plastic ultrasonic scalers, respectively, while in test group Ti-Brush was added. Infrabony defects in both groups were regenerated with BoneCeramic (Straumann, AG, Basel Switzerland) and collagen barrier membrane Cytoplast (Osteogenics, Lubbock, United States). Clinical and radiographic parameters were measured at baseline, 6, and 12 months after surgery.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Peri-implantitis reconstructive treatment implementing a titanium brush: 5-year extension results from a randomized clinical trial.
de Tapia B, Ribeiro-Amaral T, Mor C, Nart J, et al · · 2025 · cited 1× · PMID 40153369 · DOI 10.1002/jper.24-0673

Verify or expand the search:

Other trials of Titanium brush

Trials testing the same drug.

NCT03114956 — Surface Decontamination in Treatment of Peri-Implantitis · NA · withdrawn

Other recruiting trials for Peri-Implantitis

Currently open trials in the same condition.

NCT07012915 — Immunological-Clinical Evaluation of the Etiopathogenesis of Peri-Implantitis · NA · recruiting
NCT06679283 — Surgical Treatment of Peri-implantitis With Adjunctive Application of Platelet Rich Fibrin (PRF) · NA · recruiting
NCT06017817 — Antibacterial Photodynamic Therapy in the Management of Peri-implantitis · NA · recruiting
NCT06364982 — Distance Between Dental Implants as a Risk Indicator for Peri-implant Disease. · recruiting
NCT06288919 — Erythritol vs Ultrasonic Scaler Prophylaxis Systems on Dental Implants With Crowns Made by Different Materials · NA · active not recruiting

Other Universitat Internacional de Catalunya trials

Trials by the same sponsor.

NCT07478159 — Maternal Musculoskeletal Factors of the Hip, Lumbopelvic, Abdominal and Pelvic Floor Regions and Their Association With · not yet recruiting
NCT07415486 — Immediate Implants in Front Teeth With Bone Loss: Regeneration and Temporary Crown in a Randomized Clinical Study · NA · not yet recruiting
NCT07405541 — Knowledge of Periodontitis and Its Relation to Periodontal Health · not yet recruiting
NCT07417293 — Clinical and Patient Outcomes of 4 mm Ultra-Short vs. 8 mm Implants With Bone Augmentation in the Back Upper Jaw · NA · not yet recruiting
NCT07329244 — Graphene-Reinforced CAD/CAM Restorations for MIH-Affected Molars in Adolescents: A Prospective Clinical Study · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03512730 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Universitat Internacional de Catalunya
Last refreshed: 4 May 2018

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03512730.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing