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NCT07329244
Graphene-Reinforced CAD/CAM Restorations for MIH-Affected Molars in Adolescents: A Prospective Clinical Study
NA trial testing Graphene-reinforced CAD/CAM polymer (G-CAM®) in Tooth Demineralization in 30 participants. Not yet recruiting.
23 April 2026
Quick facts
| Lead sponsor | Universitat Internacional de Catalunya |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 30 |
| Start date | 10 January 2026 |
| Primary completion | 23 April 2026 |
| Estimated completion | 11 January 2027 |
| Sites | 1 location across Spain |
Drugs / interventions tested
- Graphene-reinforced CAD/CAM polymer (G-CAM®)
Conditions studied
- Tooth Demineralization — all drugs for Tooth Demineralization →
- Tooth Sensitivity — all drugs for Tooth Sensitivity →
- Enamel Mineralization Disorders — all drugs for Enamel Mineralization Disorders →
- Tooth Sensitivity After Composite Restorations — all drugs for Tooth Sensitivity After Composite Restorations →
Sponsor
Universitat Internacional de Catalunya — full company profile →
Who can join
Adults 10 to 16, any sex, with Tooth Demineralization or Tooth Sensitivity. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study evaluates the clinical performance, marginal integrity, surface wear, color stability, and postoperative sensitivity of graphene-reinforced CAD/CAM indirect restorations (inlays, onlays, overlays) in molars affected by moderate to severe Molar-Incisor Hypomineralization (MIH) in adolescents. A total of 30 patients aged 10-16 years will receive minimally invasive indirect restorations fabricated from a nano-reinforced graphene polymer (G-CAM®). Clinical outcomes will be assessed using FDI criteria, VAS sensitivity scores, patient satisfaction, and digital 3D scans over a 12-month follow-up. The study aims to determine clinical acceptability and safety compared with historical outcomes reported for composite and lithium-disilicate indirect restorations.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07329244
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07329244 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Universitat Internacional de Catalunya
- Last refreshed: 9 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07329244.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing