NCT03444259 (CAREBANK) is a clinical trial of Cardiac surgery in Atrial Fibrillation, sponsored by University of Turku.

Who is sponsoring NCT03444259?

NCT03444259 is sponsored by University of Turku.

What drugs are being tested in NCT03444259?

Interventions in NCT03444259: Cardiac surgery.

What condition does NCT03444259 study?

NCT03444259 studies Atrial Fibrillation, Coronary Artery Disease, Aortic Valve Stenosis, Aortic Valve Disease, Mitral Valve Disease, Cardiac Arrythmias, Cardiac Tumor, Cardiac Surgery.

Is NCT03444259 still recruiting?

NCT03444259 is currently active, enrolled. Last updated 8 May 2024.

Last reviewed 2024-05-08 · How we verify

NCT03444259: CAREBANK

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients

Active, enrolled Last updated 8 May 2024

What this trial tests

trial testing Cardiac surgery in Atrial Fibrillation in 1,001 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

1 February 2016

Primary endpoint
31 December 2026

31 December 2029

Quick facts

Lead sponsor	University of Turku
Status	Active, enrolled
Study type	OBSERVATIONAL
Enrollment	1,001
Start date	1 February 2016
Primary completion	31 December 2026
Estimated completion	31 December 2029
Sites	1 location across Finland

Drugs / interventions tested

Cardiac surgery

Conditions studied

Atrial Fibrillation — all drugs for Atrial Fibrillation →
Coronary Artery Disease — all drugs for Coronary Artery Disease →
Aortic Valve Stenosis — all drugs for Aortic Valve Stenosis →
Aortic Valve Disease — all drugs for Aortic Valve Disease →

Sponsor

University of Turku

Who can join

18 and older, any sex, with Atrial Fibrillation or Coronary Artery Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The objective of CAREBANK study is to establish definitive relationships with human cardiac samples and clinical phenotypes in patients undergoing cardiac procedures. Specifically, the investigators aim at comparing atrial phenotypes from atrial fibrillation patients and controls. The work consists of three broad categories: A) role of atrial cardiomyopathy in atrial fibrillation; B) genetic defects predisposing to atrial fibrillation; and C) the role of inflammation in atrial fibrillation.

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

Transcriptomic and spatial dissection of human ex vivo right atrial tissue reveals proinflammatory microvascular changes in ischemic heart disease.
Linna-Kuosmanen S, Schmauch E, Galani K, Ojanen J, et al · · 2024 · cited 14× · PMID 38776872 · DOI 10.1016/j.xcrm.2024.101556
Risk of fluid accumulation after cardiac surgery.
Koskinen A, Aittokallio J, Gunn J, Lehto J, et al · · 2023 · cited 8× · PMID 38204615 · DOI 10.1016/j.xjon.2023.10.017
Red blood cell transfusion induces abnormal HIF-1α response to cytokine storm after adult cardiac surgery.
Viikinkoski E, Jalkanen J, Gunn J, Vasankari T, et al · · 2021 · cited 7× · PMID 34782683 · DOI 10.1038/s41598-021-01695-4
Differential circulating cytokine profiles in acute coronary syndrome versus stable coronary artery disease.
Maaniitty E, Jalkanen J, Sinisilta S, Gunn J, et al · · 2024 · cited 5× · PMID 39068298 · DOI 10.1038/s41598-024-68333-7
Distinct circulating cytokine levels in patients with angiography-proven coronary artery disease compared to disease-free controls.
Maaniitty E, Sinisilta S, Jalkanen J, Vasankari T, et al · · 2024 · cited 1× · PMID 39091640 · DOI 10.1016/j.ijcrp.2024.200307
Prolonged Systemic Inflammatory Response Syndrome Predicts Atrial Fibrillation After Cardiac Surgery.
Viikinkoski E, Lehto J, Relander A, Jalkanen J, et al · · 2026 · PMID 41840772 · DOI 10.1093/icvts/ivag081

Verify or expand the search:

Other trials of Cardiac surgery

Trials testing the same drug.

NCT06958029 — Postoperative Atrial Fibrillation in Cardiac Surgery · recruiting
NCT06175650 — Towards a Sex-specific "Female Enhanced Recovery After Cardiac Surgery'' (F-ERAS) Pathway: · recruiting
NCT06078410 — Neurologic Evaluation of Patients After Transapical Beating-Heart Septal Myectomy · unknown
NCT06554925 — SEx-specific Differences in Cardiac Surgery Patients (SECS). · recruiting
NCT04487262 — Timing for Removal of Chest Tubes in Adult Cardiac Surgery · NA · terminated

Other recruiting trials for Atrial Fibrillation

Currently open trials in the same condition.

NCT07429214 — A Study of VARIPULSE Catheter and TRUPULSE Generator With VARIPULSE Pro Software in Participants With PAF or PsAF · NA · recruiting
NCT07271238 — Feasibility Study on the VERAFEYE Imaging and Navigation System for Guided Catheter Ablation Procedures · NA · recruiting
NCT07388108 — Atrial Dyssynchrony to Predict Arrhythmias in the Postoperative Setting of Cardiovascular Surgery. · recruiting
NCT07428967 — AV Node Ablation and CONDUCTion System Pacing for Atrial Fibrillation With Preserved Left Ventricular Function · NA · recruiting
NCT06650995 — AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure · NA · recruiting

Other University of Turku trials

Trials by the same sponsor.

NCT07084389 — A Financial Social Work Intervention for Families With Complex Financial Difficulties (FinSoc) · NA · recruiting
NCT06886581 — Online Training Course to Improve Evidence-based Leadership · NA · recruiting
NCT06856408 — Power of Growth - Digitally Assisted Intervention for the Early Childhood Educators' Self-efficacy Teamwork and Children · NA · recruiting
NCT06627868 — Nicotinamide Adenine Dinucleotide (NAD+) Metabolism in Human Brown Adipose Tissue · NA · recruiting
NCT06284772 — FINRISK 2002 Re-examination · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03444259 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Turku
Last refreshed: 8 May 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03444259.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing