Last reviewed · How we verify
NCT06554925: SECS
SEx-specific Differences in Cardiac Surgery Patients (SECS).
trial testing Cardiac surgery in Female in 10,000 participants. Currently enrolling.
1 March 2030
Quick facts
| Lead sponsor | Jennifer Breel |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 10,000 |
| Start date | 1 March 2022 |
| Primary completion | 1 March 2030 |
| Estimated completion | 1 March 2031 |
| Sites | 1 location across Netherlands |
Drugs / interventions tested
- Cardiac surgery
Conditions studied
- Female — all drugs for Female →
- Male — all drugs for Male →
- Surgery, Cardiac — all drugs for Surgery, Cardiac →
Sponsor
Jennifer Breel
Who can join
18 and older, any sex, with Female or Male. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of this study is to evaluate the differences between females and males undergoing cardiac surgery. The investigators will look at perioperative factors such as adaption of body weight, previous medical history, pharmacokinetics, transfusion, coagulation, cardiopulmonary bypass (CPB) related factors, cardiac function, inotropic requirements, risk, and outcome scores as well as morbidity and mortality at sort-term (within 30 days) and long-term (90 days and 1 year).
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Sex Differences in Outcomes After Elective and Acute Aortic Surgery-A Single-Centre Experience over the Last Two Decades.
Strypet M, Bozic C, Mansvelder FJ, Breel JS, et al · · 2024 · cited 2× · PMID 39518452 · DOI 10.3390/jcm13216313 -
Sex Differences in Preoperative Risk Profiles and 1-Year Mortality Following Elective Cardiac Surgery: A Retrospective Single-Centre Cohort Study.
Bozic C, Strypet M, Mansvelder FJ, Jansen EK, et al · · 2025 · PMID 41517309 · DOI 10.3390/jcm15010059
Verify or expand the search:
- PubMed search for NCT06554925
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Cardiac surgery
Trials testing the same drug.
- NCT06958029 — Postoperative Atrial Fibrillation in Cardiac Surgery · recruiting
- NCT06175650 — Towards a Sex-specific "Female Enhanced Recovery After Cardiac Surgery'' (F-ERAS) Pathway: · recruiting
- NCT06078410 — Neurologic Evaluation of Patients After Transapical Beating-Heart Septal Myectomy · unknown
- NCT04487262 — Timing for Removal of Chest Tubes in Adult Cardiac Surgery · NA · terminated
- NCT04366167 — Patient Recovery From Heart Surgery During the Covid-19 Pandemic · completed
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Other Jennifer Breel trials
Trials by the same sponsor.
- NCT06175650 — Towards a Sex-specific "Female Enhanced Recovery After Cardiac Surgery'' (F-ERAS) Pathway: · recruiting
- NCT02112474 — The Pain Suppressive Effect of Alternative Spinal Cord Stimulation Frequencies · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06554925 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Jennifer Breel
- Last refreshed: 15 August 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06554925.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing