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NCT03378557: PPFx
Periprosthetic Fracture Registry (PPFx)
trial in Periprosthetic Fractures in 600 participants. Currently enrolling.
31 January 2027
Quick facts
| Lead sponsor | AO Innovation Translation Center |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 600 |
| Start date | 31 December 2018 |
| Primary completion | 31 January 2027 |
| Estimated completion | 31 March 2027 |
| Sites | 13 locations across Colombia, Belgium, Germany, Switzerland, United States, Spain |
Conditions studied
- Periprosthetic Fractures — all drugs for Periprosthetic Fractures →
- Periprosthetic Fracture Around Prosthetic Joint Implant — all drugs for Periprosthetic Fracture Around Prosthetic Joint Implant →
Sponsor
AO Innovation Translation Center
Who can join
18 and older, any sex, with Periprosthetic Fractures or Periprosthetic Fracture Around Prosthetic Joint Implant. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This registry supports international data collection and research on PPFx treatments after hip and knee arthroplasty. A registry such as this ultimately aims to provide far-reaching benefits to society including reduced morbidity and mortality, improved patient safety, improved quality of care and medical decision-making, reduced medical spending, and advances in orthopaedic science.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Fracture fixation versus revision arthroplasty in Vancouver type B2 and B3 periprosthetic femoral fractures: a systematic review.
Stoffel K, Blauth M, Joeris A, Blumenthal A, et al · · 2020 · cited 58× · PMID 32086558 · DOI 10.1007/s00402-020-03332-7 -
Periprosthetic Femoral Fractures-Beyond B2.
Uzoigwe CE, Watts AT, Briggs P, Symes T. · · 2024 · cited 2× · PMID 39110721 · DOI 10.5435/jaaosglobal-d-23-00135
Verify or expand the search:
- PubMed search for NCT03378557
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Periprosthetic Fractures
Currently open trials in the same condition.
- NCT06028971 — Safety and Performance of the Biphasic Plate Distal Femur: A Multicenter Case Series · active not recruiting
- NCT04663893 — Peri-Implant and Peri-Prosthetic Fractures: Epidemiology, Morbidity, Mortality, Treatment and Outcome Analysis · recruiting
Other AO Innovation Translation Center trials
Trials by the same sponsor.
- NCT07199075 — Rate of Bone Union After Surgery With Stand-alone Fibergraft · not yet recruiting
- NCT06845293 — AO CSH Mainstream Study on Cervical Spine Degeneration · not yet recruiting
- NCT04921865 — Case Series on the Clinical Performance of VA Clavicle and Clavicle Hook Plate 2.7 Systems · recruiting
- NCT04112992 — An International, Multicenter, Prospective Registry on Post-traumatic Long Bones Defects · recruiting
- NCT04098146 — Registry to Collect Data on Patients Undergoing Segmental Mandibular Defect Reconstruction Following Oral Squamous Cell · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03378557 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by AO Innovation Translation Center
- Last refreshed: 12 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03378557.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing