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NCT04112992
An International, Multicenter, Prospective Registry on Post-traumatic Long Bones Defects
trial testing Any treatment that is used for a defect of any long bone in Limb Fracture in 600 participants. Currently enrolling.
31 May 2028
Quick facts
| Lead sponsor | AO Innovation Translation Center |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 600 |
| Start date | 3 July 2024 |
| Primary completion | 31 May 2028 |
| Estimated completion | 30 March 2029 |
| Sites | 21 locations across Colombia, Netherlands, South Africa, Ukraine, Chile, United Kingdom, Germany, South Korea |
Drugs / interventions tested
- Any treatment that is used for a defect of any long bone
Conditions studied
- Limb Fracture — all drugs for Limb Fracture →
- Bone Loss — all drugs for Bone Loss →
Sponsor
AO Innovation Translation Center
Who can join
18 and older, any sex, with Limb Fracture or Bone Loss. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Long bone defect (LBD) is defined as a focalized loss of bone tissue in any long bone of the upper or lower extremity. Long bone defects are a complex problem, that may arise as a complication of many different pathologies, such as trauma, tumors or infection. Whereas post-traumatic defects are the largest group. Reports estimate that there are almost 4 million bone grafting procedures worldwide per year. However, limb reconstruction in the context of a bony defect is challenging and up to date there is little evidence and treatment recommendations. In a multi-national approach, the aim of this project is to set up an international, multicenter registry to gather information and details on prevalence or incidence, current treatments, complications and outcome.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Scaffold Guided Bone Regeneration for the Treatment of Large Segmental Defects in Long Bones.
Schulze F, Lang A, Schoon J, Wassilew GI, et al · · 2023 · cited 31× · PMID 36830862 · DOI 10.3390/biomedicines11020325
Verify or expand the search:
- PubMed search for NCT04112992
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other AO Innovation Translation Center trials
Trials by the same sponsor.
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- NCT04098146 — Registry to Collect Data on Patients Undergoing Segmental Mandibular Defect Reconstruction Following Oral Squamous Cell · recruiting
- NCT04207892 — Registry of Pediatric Orthopedic Trauma and Health Outcomes in Skeletally Immature Children · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04112992 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by AO Innovation Translation Center
- Last refreshed: 29 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04112992.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing