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NCT04098146
Registry to Collect Data on Patients Undergoing Segmental Mandibular Defect Reconstruction Following Oral Squamous Cell Carcinoma Resection and Drugs-induced Osteonecrosis
trial testing Surgical Resection and Reconstruction in Mandibular Reconstruction in 300 participants. Currently enrolling.
30 June 2030
Quick facts
| Lead sponsor | AO Innovation Translation Center |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 300 |
| Start date | 12 September 2022 |
| Primary completion | 30 June 2030 |
| Estimated completion | 31 December 2030 |
| Sites | 19 locations across Netherlands, Japan, Sweden, Germany, Switzerland, Portugal, United States, Spain |
Drugs / interventions tested
- Surgical Resection and Reconstruction
Conditions studied
- Mandibular Reconstruction — all drugs for Mandibular Reconstruction →
- Segmental Mandibular Defects — all drugs for Segmental Mandibular Defects →
Sponsor
AO Innovation Translation Center
Who can join
18 and older, any sex, with Mandibular Reconstruction or Segmental Mandibular Defects. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Prospective will be collected in a minimum of 300 patients presenting with an acquired segmental mandibular defect ≥ 2 cm secondary to OSSC removal and drugs-induced osteonecrosis, and who require mandibular reconstruction.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Biomaterials-based additive manufacturing for customized bioengineering in management of otolaryngology: a comprehensive review.
Vyas J, Shah I, Singh S, Prajapati BG. · · 2023 · cited 10× · PMID 37744247 · DOI 10.3389/fbioe.2023.1234340
Verify or expand the search:
- PubMed search for NCT04098146
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Mandibular Reconstruction
Currently open trials in the same condition.
- NCT07320924 — Patient-specific Reconstruction Plate for Segmental Mandibular Defects · NA · recruiting
- NCT07221916 — Stryker's Surgeon iD Mandible Reconstruction Plates: A Retrospective Post Market Follow Up · recruiting
Other AO Innovation Translation Center trials
Trials by the same sponsor.
- NCT07199075 — Rate of Bone Union After Surgery With Stand-alone Fibergraft · not yet recruiting
- NCT06845293 — AO CSH Mainstream Study on Cervical Spine Degeneration · not yet recruiting
- NCT04921865 — Case Series on the Clinical Performance of VA Clavicle and Clavicle Hook Plate 2.7 Systems · recruiting
- NCT04112992 — An International, Multicenter, Prospective Registry on Post-traumatic Long Bones Defects · recruiting
- NCT04207892 — Registry of Pediatric Orthopedic Trauma and Health Outcomes in Skeletally Immature Children · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04098146 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by AO Innovation Translation Center
- Last refreshed: 4 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04098146.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing